RB 90740
a fused pyrazine mono-N-oxide; structure given in first source
Also Known As:
1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo(1,2-a)pyrido(3,2-e)pyrazine 5-oxide; RB-90740; RB90740
Networked: 7
relevant articles (1 outcomes,
1 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Cabrera, Mauricio:
1 article
(02/2009)
|
2. | Cerain, Adela López de:
1 article
(02/2009)
|
3. | Cerecetto, Hugo:
1 article
(02/2009)
|
4. | Gambino, Dinorah:
1 article
(02/2009)
|
5. | Garat, Beatriz:
1 article
(02/2009)
|
6. | González, Mercedes:
1 article
(02/2009)
|
7. | Lavaggi, María Laura:
1 article
(02/2009)
|
8. | Monge, Antonio:
1 article
(02/2009)
|
9. | Smircich, Pablo:
1 article
(02/2009)
|
10. | Torre, María H:
1 article
(02/2009)
|
Related Diseases
1. | Neoplasms (Cancer)
04/01/1995
- " Despite these properties demonstrated in vitro, RB 90740 was shown not to be cytotoxic to hypoxic cells in experimental murine tumors in vivo. " 01/01/1996
- " This new series of bioreductive compounds may be effective in cancer therapy, particularly the lead compound RB 90740. " 05/15/1994
- " To study the reduction of RB90740 (1), a fused pyrazine mono-N-oxide that has an oxic:hypoxic cytotoxicity ratio of > 10 in a range of murine and human tumor cells in vitro. " 01/01/1994
- " These compounds had differential cytotoxicities in vitro of up to 20 for 8-amino derivatives such as RB90740 and 65 for 8-aminoalkoxy derivatives such as 1,2-dihydro-8-(1-(demethylamino)ethoxy)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide, but were disappointing in vivo with a maximum growth delay of 10 days compared with 30 days for SR4233 in the RIF-1 tumor model. " 05/15/1994
- " RIF-1 tumors implanted intradermally in C3H mice were treated with either 50J photodynamic therapy or with 120 min clamping in combination with either misonidazole, pimonidazole, metronidazole, nimorazole, RB6145, RSU1069, SR4233, mitomycin-C, or RB90740. "
|
2. | Hypoxia (Hypoxemia)
|
|
Related Drugs and Biologics
Related Therapies and Procedures