K cadherin

preferentially expressed in fetal kidney and kidney carcinoma; RefSeq NM_007666 (mouse); NM_012927 (rat); NM_004932 (human)

Also Known As:

CDH6 protein, human; Cdh6 protein, mouse; Cdh6 protein, rat; K-cadherin; K-cadherin protein, Xenopus; K-cadherin protein, human; K-cadherin protein, mouse; K-cadherin protein, rat; Kcad protein, rat; Xcad-6 protein, Xenopus; cadherin 6 protein, mouse; cadherin 6 protein, rat; cadherin 6, type 2 protein, Xenopus; cadherin 6, type 2 protein, human; cadherin-6; cdh6 protein, Xenopus; kidney cadherin

Networked: 28 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Akaza, Hideyuki: 3 articles (05/2006 - 10/2003)
2.	Shimazui, Toru: 3 articles (05/2006 - 10/2003)
3.	Genin, Christian: 2 articles (01/2005 - 12/2003)
4.	Gentil-Perret, Anne: 2 articles (01/2005 - 12/2003)
5.	Lambert, Claude: 2 articles (01/2005 - 12/2003)
6.	Li, Guorong: 2 articles (01/2005 - 12/2003)
7.	Passebosc-Faure, Karine: 2 articles (01/2005 - 12/2003)
8.	Tostain, Jacques: 2 articles (01/2005 - 12/2003)
9.	Hirao, Yoshihiko: 2 articles (09/2004 - 10/2003)
10.	Saga, Shinsuke: 2 articles (09/2004 - 10/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Cadherin-6 (CDH6) is aberrantly expressed in cancer and closely associated with tumor progression. " 01/01/2013 - "Recently, we found Cadherin-6 (CDH6, also known as K-CAD) highly expressed in thyroid tumor cells that display mesenchymal features and aggressive phenotype, following the overexpression of the transcriptional regulator Id1. " 01/01/2005 - "Cadherin-6 is a useful molecular marker to detect the circulating cancer cells disseminated from conventional RCC." 01/01/2004 - "We prospectively evaluated the importance of cadherin-6 in renal tumors in a large cohort of patients. " 10/01/1998 - "Hence, we have investigated the relationship between prognosis and cadherin-6 expression in tumor cells in 43 patients with RCC. "
2.	Renal Cell Carcinoma (Grawitz Tumor) 01/01/2004 - "In our prospective analysis the pattern of cadherin-6 expression correlated with known prognostic factors of renal cell cancer on univariate and multivariate analysis. " 01/01/2004 - "We developed a relative risk factor for renal cell cancer for our patients using the multivariate proportional hazard Cox model, which showed a statistically significant correlation with cadherin-6 expression (p = 0.028). " 01/01/2004 - "Cadherin-6 expression in renal cell cancer correlated with known prognostic factors, such as pT stage (p = 0.03), pN stage (p = 0.001), histological growth pattern (p = 0.001), M stage (p = 0.06) and renal venous involvement (p = 0.019). " 01/01/2004 - "First results demonstrated that the expression of cadherin-6 in renal cell carcinoma may have prognostic value. " 07/01/1997 - "Overall, these findings demonstrate specific expression of cadherin-6 in the proximal renal tubules in normal human kidney and suggest that alterations of cadherin-6 expression are associated with progression of renal cell carcinoma."
3.	Kidney Neoplasms (Kidney Cancer) 01/01/2004 - "Our data suggest that cadherin-6 is a new prognostic factor for renal cancer." 06/01/1994 - "The level of K-cadherin expression was also elevated in some human kidney cancer tissues. " 06/01/1994 - "These results demonstrate that K-cadherin must have important functions in both the process of kidney development and tumorigenesis of some types of kidney cancer." 01/01/2005 - "In this study, we evaluated cadherin-6 mRNA as a new molecular marker for the detection of circulating renal cancer cells. " 01/01/2017 - "We identified the cell-cell adhesion molecule cadherin-6 (CDH6) as a lineage gene having significant differential expression in ovarian and kidney cancers. "
4.	Neoplasm Metastasis (Metastasis) 09/01/2004 - "Cadherin-6 was found in 69.9% of patients with metastases and in 34.9% of patients without apparent metastases (P = 0.0099). " 09/01/2004 - "Among 43 patients with newly diagnosed RCC, 5 of 15 patients who were positive for cadherin-6 had metastases after nephrectomy, whereas only 2 of the 28 patients with negative cadherin-6 status had recurrent disease (P = 0.0398). " 01/01/2017 - "Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy." 09/01/2004 - "However, subsequent metastases did not always correlate with levels of cadherin-6 mRNA. " 09/01/2004 - "The quantification of cadherin-6 mRNA in peripheral blood may be a significant predictive marker for current and future metastases. "
5.	Ocular Hypertension (Glaucoma, Suspect) 01/01/2018 - "Our in vivo study showed that K-cadherin significantly decreased sFRP1-induced ocular hypertension (P < 0.05, n = 6). "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Cadherins (E-Cadherin)
3.	Cell Adhesion Molecules
4.	Proteins (Proteins, Gene)
5.	Complementary DNA (cDNA)
6.	K cadherin
7.	Orphan Nuclear Receptors
8.	Neuropilin-1
9.	Aquaporins (Water Channels)
10.	Cell Cycle Proteins

Related Therapies and Procedures

1.	Nephrectomy