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U 89678

structure given in first source

Also Known As:

U-89678

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnatrienes
        U 89678: 3

Related Diseases

1.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 02/01/1996 - "Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury."
2.	Craniocerebral Trauma (Head Injury) 04/01/1997 - "The pharmacokinetics of tirilazad and U-89678 (an active metabolite) were evaluated in 55 adults (48 males, 7 females) with moderate or severe head injury who received 10.0 mg/kg/day tirilazad mesylate for 5 days. " 04/01/1997 - "Pharmacokinetics of tirilazad and U-89678, an active, reduced metabolite, following acute head trauma in adults."
3.	Ischemic Stroke 09/01/1996 - "These results show that gender has a modest effect on the pharmacokinetics of U-89678 but little effect on the pharmacokinetics of tirilazad in elderly ischemic stroke patients. " 09/01/1996 - "The pharmacokinetics of tirilazad mesylate and its active reduced metabolite, U-89678, were evaluated in ischemic stroke patients receiving 2.5 mg/kg tirilazad every 3 hours for the first 12 hours of dosing followed by 2.5 mg/kg every 6 hours for a total of 22 doses (5 days). " 09/01/1996 - "Pharmacokinetics of tirilazad and U-89678 in ischemic stroke patients receiving a loading regimen and maintenance regimen of 10 mg/kg/day of tirilazad."

Related Drugs and Biologics

1.	tirilazad
2.	Lipids