Mel T

formed by reaction of trypanothione with trivalent arsenicals; inhibits trypanothione reductase

Also Known As:

4-(4,6-diamino-s-triazin-2-yl)aminophenylarsenoxide dihydrotrypanothione adduct; Mel-T; MelT adduct; melarsen oxide - dihydrotrypanothione adduct

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Appelbaum, F R: 1 article (09/2001)
2.	Bensinger, W I: 1 article (09/2001)
3.	Buckner, C D: 1 article (09/2001)
4.	Golden, J: 1 article (09/2001)
5.	Gutierrez-Delgado, F: 1 article (09/2001)
6.	Holmberg, L A: 1 article (09/2001)
7.	Hooper, H: 1 article (09/2001)
8.	Maloney, D G: 1 article (09/2001)
9.	Maziarz, R T: 1 article (09/2001)
10.	Press, O W: 1 article (09/2001)

Related Diseases

1.	Lymphoma (Lymphomas) 09/01/2001 - "The aim of this study was to compare toxicity and efficacy of total body irradiation (TBI), cyclophosphamide (CY) and etoposide (E) (TBI/CY/E) vs busulfan, melphalan and thiotepa (Bu/Mel/T) in patients receiving autologous stem cell infusion (ASCI) for malignant lymphoma (NHL). "
2.	Melanoma (Melanoma, Malignant) 01/01/1988 - "The mutant and natural t-PA (Mel-t-PA obtained from melanoma cell culture) were infused intravenously for four hours into rabbits with jugular vein thrombosis at doses ranging between 0.12 and 0.75 mg/kg. Fifty percent thrombolysis, determined by interpolation, was obtained with 0.4 mg/kg Mel-t-PA, 0.37 mg/kg t-PA-delta FE, 0.2 mg/kg t-PA-delta FE1X, and 0.40 mg/kg t-PA-delta FE3X. " 12/15/1984 - "A mouse MAb3 50H.19 raised against the human melanoma cell line MEL-T binds to carcinoma cell lines, carcinoma biopsy material, and certain epithelia of normal tissues. "
3.	Thrombosis (Thrombus) 01/01/1988 - "The mutant and natural t-PA (Mel-t-PA obtained from melanoma cell culture) were infused intravenously for four hours into rabbits with jugular vein thrombosis at doses ranging between 0.12 and 0.75 mg/kg. Fifty percent thrombolysis, determined by interpolation, was obtained with 0.4 mg/kg Mel-t-PA, 0.37 mg/kg t-PA-delta FE, 0.2 mg/kg t-PA-delta FE1X, and 0.40 mg/kg t-PA-delta FE3X. "
4.	Carcinoma (Carcinomatosis) 12/15/1984 - "A mouse MAb3 50H.19 raised against the human melanoma cell line MEL-T binds to carcinoma cell lines, carcinoma biopsy material, and certain epithelia of normal tissues. "

Related Drugs and Biologics

1.	Thiotepa (Triethylenethiophosphoramide)
2.	Melphalan (Alkeran)
3.	Etoposide (VP 16)
4.	Cyclophosphamide (Cytoxan)
5.	Busulfan (Busulfex)