glutathione transporter

Also Known As:

ATMRP4 protein, Arabidopsis; GS-X pump; GSH transporter; MRP4 protein, Arabidopsis; RcGshT protein; RcGshT protein, rat; glutathione S-conjugate export pump; glutathione transport proteins; rat canalicular GSH transporter

Networked: 24 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - glutathione transporter: 24
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - glutathione transporter: 24

Experts

1.	Chen, Yufan: 1 article (07/2008)
2.	Chow, Pierce: 1 article (07/2008)
3.	Goh, Kenneth: 1 article (07/2008)
4.	Jin, Yi: 1 article (07/2008)
5.	Ong, Laichun: 1 article (07/2008)
6.	Zhang, Kai: 1 article (07/2008)
7.	Zheng, Lin: 1 article (07/2008)
8.	Curi, Rui: 1 article (01/2006)
9.	Heck, Thiago Gomes: 1 article (01/2006)
10.	Kolberg, Angela: 1 article (01/2006)

Related Diseases

1.	Leukemia 11/18/1994 - "The present study provides evidence that the GS-X pump is functionally overexpressed in cisplatin-resistant human promyelocytic leukemia HL-60 (HL-60/R-CP) cells, in which the cellular GSH level was substantially enhanced. " 11/18/1994 - "GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation." 06/21/1996 - "Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells." 01/01/1996 - "We provide evidence that the expression of the human MRP/GS-X pump encoded by the MRP (multidrug resistance associated protein) gene is induced by cisplatin in human leukemia HL-60/R-CP (cisplatin-resistant) cells and modulates cell growth inhibition by delta(7)-prostaglandin A1 (PGA1) methyl ester. " 06/21/1996 - "We recently reported that GS-X pump activity, as assessed by ATP-dependent transport of the glutathione-platinum complex and leukotriene C4, and intracellular glutathione (GSH) levels were remarkably enhanced in cis-diamminedichloroplatinum(II) (cisplatin)-resistant human leukemia HL-60 cells (Ishikawa, T., Wright, C. "
2.	Colonic Neoplasms (Colon Cancer) 11/12/1996 - "This study demonstrates the presence and kinetic measurements of the glutathione S-conjugate export (GS-X) pump in human colon cancer cells, an export pump whose function has been implicated in the phenomenon of multidrug resistance."
3.	Neoplasms (Cancer) 04/01/1999 - "Overall, a clear difference in substrate specificity among GS-X pump family members expressed on resistant tumor cells was demonstrated." 12/15/1998 - "The GS-X pump is suggested to play a pivotal role in modulating the biological action of the anti-cancer PG." 09/01/1998 - "These results support the proposition that the accumulation of CP-PGs and the immunosuppression of tumor-bearing subjects may be attributed to a lack of GS-X pump activity/expression in lymphocytes." 09/01/1998 - "Different cancer cell lines exhibited characteristically different GS-X pump activity. " 07/01/2008 - "Its combined effects on GST and glutathione conjugate export (GS-X) pump may provide more potent sensitisation of cancer cells to chemotherapeutic drugs."
4.	Colorectal Neoplasms (Colorectal Cancer) 08/15/1996 - "Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers." 11/01/2000 - "Treatment of human colorectal cancer cells HT29 with interleukin 1beta (IL-1beta) induces expression of the multidrug resistance protein (MRP1) gene encoding the ATP-dependent glutathione S-conjugate export (GS-X) pump and the gamma-glutamylcysteine synthetase (gamma-GCSh) gene encoding heavy (catalytic) subunit of gamma-glutamylcysteine synthetase, the rate-limiting enzyme for the biosynthesis of glutathione (GSH). "
5.	Glioma (Gliomas) 12/01/1997 - "Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells." 10/09/1997 - "Posttranscriptional regulation of MRP/GS-X pump and gamma-glutamylcysteine synthetase expression by 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea and by cycloheximide in human glioma cells."

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Cisplatin (Platino)
3.	gamma-glutamylcysteine
4.	Ligases (Synthetase)
5.	Multidrug Resistance-Associated Proteins
6.	Adenosine Triphosphate (ATP)
7.	multidrug resistance-associated protein 1
8.	Prostaglandins
9.	Adenosine Triphosphatases (ATPase)
10.	glutathione transporter

Related Therapies and Procedures

1.	Therapeutics