acetyl 4-aminosalicylic acid

01/01/2021 - "Pre-rheumatoid arthritis and ACPA: Contribution of ACPAs in the pathogeny of pre-disease stage."
01/01/2019 - "Promiscuous ACPAs tend to dominate in the sera both before and after the onset of rheumatoid arthritis, but their functional role has not been clarified. "
09/01/2018 - "On the other hand, after their production by plasma B cells, ACPAs are also able to interact with innate immunity to exacerbate the manifestation and chronicity of rheumatoid arthritis (RA). "
11/01/2017 - "Population-based screening for ACPAs: a step in the pathway to the prevention of rheumatoid arthritis?"
02/01/2016 - "Rheumatoid arthritis: Osteoclasts and ACPAs--the joint link."

08/23/2023 - "This study highlights a potential protective role for ACPAs in arthritis."
03/01/2019 - "Studies were included if they: assessed the association of arthritis and ACPAs, had sufficient data to construct a two-by-two table, tested immunoglobulin G ACPA by any method, and included patients with pSS according to a validated set of classification criteria. "
08/23/2023 - "Despite substantial in vitro evidence supporting this claim, reports investigating the proinflammatory effects of ACPAs in animal models of arthritis are rare and include mixed results. "
03/01/2019 - "Patients with pSS disclosing ACPAs are prone to arthritis as part of the clinical spectrum of the disease, but are also at risk of developing RA."
07/06/2017 - "Overall, we have demonstrated a molecular mechanism that explains how ACPAs trigger arthritis."

04/01/2014 - "The aim of this study was to evaluate the epidemiologic and molecular interaction of ACPAs and RF and its association with both disease activity and measures of RA-associated inflammation. "
12/01/2023 - "RA patients may experience mild to moderate liver inflammation due to the infiltration of T, B cells, and macrophages, and the action of ACPAs. "
12/01/2023 - "ACPAs induced a defective hepatocyte function, promoting IR and inflammation. "
06/04/2020 - "Although our knowledge of the generation and production of ACPAs has continuously advanced during the past decade, our understanding on the pathogenic mechanisms of how ACPAs interact with immune cells to trigger articular inflammation is relatively limited. "
01/01/2019 - "However, due to the close association between joint inflammation and ACPAs, a more direct role of ACPAs in the immunopathogenesis of RA is anticipated. "

01/01/2019 - "These studies establish fibrinogen as a common target for both RF and ACPAs, and suggest a new mechanism in RF-mediated autoimmune diseases wherein RF may act as a precursor from which the ACPA response evolves."
09/15/2011 - "This work reports on the fabrication and performance of a simple amperometric immunosensor device to be potentially used for the detection of serum anti-citrullinated peptide antibodies (ACPAs), which are specific for rheumatoid arthritis (RA) autoimmune disease. "
01/01/2022 - "The strong association is observed despite totally different aetiology of these two diseases, periodontitis being driven by dysbiotic microbial flora on the tooth surface below the gum line, while rheumatoid arthritis being the autoimmune disease powered by anti-citrullinated protein antibodies (ACPAs). "
11/18/2020 - "A hallmark of rheumatoid arthritis (RA), a common autoimmune disease, is the presence of disease-specific anticitrullinated protein antibodies (ACPAs). "
05/01/2016 - "The objectives of this study are to investigate the prevalence of PAD4 and anti-PAD4 antibodies (Abs) in autoimmune diseases and to clarify their association with anticitrullinated protein antibodies (ACPAs) and shared epitope (SE) in patients with rheumatoid arthritis (RA). "

01/01/2018 - "Recent in vitro and murine studies indicate that ACPAs can directly activate osteoclasts leading to bone erosions and pain. "
01/01/2023 - "The combination of 2 monoclonal ACPAs (1325:04C03 and 1325:01B09) induced long-lasting pain-like behavior and trabecular bone loss in mice. "
01/01/2023 - "Patient-derived ACPAs have been shown to induce pain and bone erosion in mice, suggesting an active role in the pathogenicity of RA. "
01/01/2023 - "None of the ACPAs showed arthritogenicity nor induced pain-associated behavior in mice. "
01/01/2023 - "Monoclonal ACPAs can induce tenosynovitis in addition to pain and bone loss via mechanisms dependent on PAD4-mediated citrullination."