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SM 10906

a prostacyclin I1 (PGI1) analog; structure given in first source

Also Known As:

SM-10906

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins I: 108
        Epoprostenol: 4670
        SM 10906: 3
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins I: 108
        Epoprostenol: 4670
        SM 10906: 3

Related Diseases

1.	Ganglion Cysts (Ganglion) 04/01/1994 - "SM-10906 given intravenously exhibited a sustained reduction in blood pressure based on vasodilation in ganglion-blocked, angiotensin II-supported rats. "
2.	Mastocytoma 01/01/1994 - "These results demonstrate that SM-10906, a stable PGI1 derivative, is an agonist for the [3H]iloprost-binding (PGI2) receptor, and that it prevents thrombin-induced Ca2+ mobilization through stimulation of the adenylate cyclase system in mastocytoma cells. " 01/01/1994 - "Prostacyclin (PGI) receptor binding and cyclic AMP synthesis activities of PGI1 analogues, SM-10906 and its methyl ester, SM-10902, in mastocytoma P-815 cells." 01/01/1994 - "The prostacyclin I1 (PGI1) analogue, SM-10906 and its methyl ester, SM-10902, have been compared with the PGI2 analogue, iloprost, with respect to binding to the PGI2 receptor, stimulation of adenylate cyclase activity and inhibition of thrombin-induced Ca2+ mobilization in mastocytoma P-815 cells. "
3.	Hypertrophic Cicatrix (Hypertrophic Scar) 12/01/1997 - "The mode of action of prostaglandin (PG) I1 analog, SM-10906, on fibroblasts of hypertrophic scars is similar to PGE1 in its potential role of preventing scar formation." 12/01/1997 - "The effects of prostaglandin (PG) I1 analog, SM-10906 (SM-6) and PGE1 on extracellular matrix formation and the release of cytokines by cultured normal human dermal fibroblasts (NDF) and hypertrophic scar fibroblasts (HSF) were compared in order to evaluate the clinical efficacy of PGs in preventing scar formation. "
4.	Cicatrix (Scar) 12/01/1997 - "The mode of action of prostaglandin (PG) I1 analog, SM-10906, on fibroblasts of hypertrophic scars is similar to PGE1 in its potential role of preventing scar formation." 12/01/1997 - "The effects of prostaglandin (PG) I1 analog, SM-10906 (SM-6) and PGE1 on extracellular matrix formation and the release of cytokines by cultured normal human dermal fibroblasts (NDF) and hypertrophic scar fibroblasts (HSF) were compared in order to evaluate the clinical efficacy of PGs in preventing scar formation. "

Related Drugs and Biologics

1.	Epoprostenol Receptors
2.	Iloprost (Ventavis)
3.	Cytokines
4.	Thrombin
5.	Epoprostenol (Prostacyclin)
6.	Prostaglandins
7.	Esters
8.	Angiotensin II
9.	Alprostadil (Muse)
10.	Adenylyl Cyclases (Adenylyl Cyclase)