lambda Spi-1

belongs to serine protease inhibitor family; from rat liver; Spi-1 & Spi-2 have 87% amino acid identity; amino acid sequence has been determined; do not confuse with Spi-1 transcription factors

Also Known As:

Networked: 104 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Desin, Taseen S: 3 articles (01/2019 - 07/2009)
2.	Coombes, Brian K: 3 articles (07/2017 - 11/2005)
3.	Hardt, Wolf-Dietrich: 3 articles (01/2013 - 02/2004)
4.	Potter, Andrew A: 3 articles (03/2011 - 11/2005)
5.	Adams, L Garry: 2 articles (01/2019 - 02/2014)
6.	Moss, Bernard: 2 articles (01/2019 - 11/2005)
7.	Suar, Mrutyunjay: 2 articles (01/2018 - 01/2013)
8.	Bustamante, Víctor H: 2 articles (07/2017 - 01/2015)
9.	Pérez-Morales, Deyanira: 2 articles (07/2017 - 01/2015)
10.	Kitagawa, Masanobu: 2 articles (05/2012 - 08/2005)

Related Diseases

1.	Infections 12/01/2008 - "Recent studies have revealed a critical role for the SPI-1 effector SopB in 'directing traffic' at early stages of infection, allowing the bacteria to control SCV maturation by modulating its interaction with the endocytic system. " 10/16/2008 - "In our study, we highlight important differences in systemic and intestinal colonization levels between chick and murine serotype Typhimurium infections, and provide evidence that suggests that the role of SPI-1 may not be the same during colonization of both animal models." 10/06/2023 - "Identification of this lineage follows the previous detection of another lineage over-represented in swine compared with humans which carries a loss-of-function mutation in hilD, the major SPI-1 regulator, responsible for reduced infection of human cells. " 01/01/2021 - "Here, we use the three-dimensional human intestinal organoid model to define early responses to infection with wild-type S Typhimurium and mutants defective in the SPI-1 or SPI-2 type-3 secretion systems. " 01/01/2021 - "These findings from Salmonella-infected HIOs delineate common and distinct contributions of SPI-1 and SPI-2 T3SSs in inducing early host responses during enteric infection and reinforce host cell proliferation as a process targeted by SalmonellaIMPORTANCESalmonella enterica serovar Typhimurium (S Typhimurium) causes a significant health burden worldwide, yet host responses to initial stages of intestinal infection remain poorly understood. "
2.	Salmonella Infections (Salmonellosis) 07/25/2023 - "The aim of this study was to evaluate the effect of the deletion of SPI-1 or SPI-2 genes on the intestinal and systemic salmonellosis using the avian model. " 07/01/2011 - "The previously unrecognized strain heterogeneity in SPI-1 expression and invasiveness has important implications for studies of Salmonella infection." 01/01/2019 - "Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia." 01/01/2014 - "The possible correlation between attenuation of Salmonella infection in the chicken spleen and liver and reduction of Salmonella SPI-1 virulence gene expression in the chicken cecum by LAB isolates is a new observation. " 11/01/2005 - "These data delineate novel phenotypes for SPI-1 and SPI-2 mutants in the intestinal phase of bovine and murine salmonellosis and provide working models to further investigate the effector contribution to these pathologies."
3.	Diarrhea 10/06/2022 - "Compared with the non-drought period, SPI-1 showed the strongest correlation between middle drought and pediatric diarrhea outpatients, with an increase of 13.4% (95%CI: 7.9%-19.3%) and 20.0% (95%CI: 12.7%-27.8%) in Lanzhou city and Tianshui city, respectively. " 10/01/2011 - "SPI-1 genes are not essential for the diarrhea caused by S. " 09/01/1999 - "Mutations in SPI-1 (hilA and prgH) or aroA markedly reduced virulence and the severity of diarrhea. " 02/13/2008 - "A SPI-1 (invA) mutant caused cecal, but not colonic inflammation and did not cause diarrhea. " 04/01/2008 - "Recent studies of Salmonella enterica infection models have demonstrated that enterocolitis and diarrhea in mice and cows can occur independently of SPI-1. "
4.	Polycythemia (Erythrocytosis) 01/01/1990 - "In previous studies it has been described that the late malignant proerythroblastic transformation induced by the polycythemia-inducing strain of Friend spleen focus-forming virus (SFFVP) is correlated with Spi-1 oncogene activation by insertional mutagenesis. "
5.	Enterocolitis 04/01/2008 - "Recent studies of Salmonella enterica infection models have demonstrated that enterocolitis and diarrhea in mice and cows can occur independently of SPI-1. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Epitopes
3.	Cytokines
4.	Transcription Factors (Transcription Factor)
5.	Type III Secretion Systems
6.	Messenger RNA (mRNA)
7.	Minichromosome Maintenance Complex Component 4
8.	Inflammasomes
9.	Cathepsin K
10.	Chromatin Assembly Factor-1

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Hypophysectomy