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4-amino-1,8-naphthalimide

inhibits ADP-ribosylation; sometimes abreviated as 4-AN;

Also Known As:

4-amino1,8-naphthalimide

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Adair, Liam D: 1 article (08/2020)
2.	Jacquemin, Denis: 1 article (08/2020)
3.	Jolliffe, Katrina A: 1 article (08/2020)
4.	New, Elizabeth J: 1 article (08/2020)
5.	Trinh, Natalie: 1 article (08/2020)
6.	Vérité, Pauline M: 1 article (08/2020)
7.	Arisa, Tobi: 1 article (04/2018)
8.	Dalton, Hannah L: 1 article (04/2018)
9.	Estalayo-Adrián, Sandra: 1 article (04/2018)
10.	Gunnlaugsson, Thorfinnur: 1 article (04/2018)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 06/01/2015 - "In this study, we investigated ATO sensitization and detoxification effect of the Poly (ADP ribose) polymerase-1 (PARP-1) inhibitor 4-Amino-1,8-naphthalimide (4AN) in the hepatocellular carcinoma cell line HepG2. "
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2009 - "Benzamide (BA) and 4-amino-1,8-naphthalimide (NAP), two well-known inhibitors of PARP, treatment increased nuclear fragmentation and caspase-3 activity in HeLa (Human cervical cancer cell line) cells. " 04/19/2018 - "The synthesis, photophysics and biological investigation of fluorescent 4-amino-1,8-naphthalimide Tröger's bases (TB-1-TB-3) and a new Tröger's base p-cymene-Ru(ii)-curcumin organometallic conjugate (TB-Ru-Cur) are described; these compounds showed fast cellular uptake and displayed good luminescence and cytotoxicity against cervical cancer cells."
3.	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 04/22/2005 - "Both wild-type and, in particular, repair-deficient DNA polymerase beta null cells are highly sensitized to the cytotoxic effects of MMS by 4-amino-1,8-naphthalimide (4-AN), an inhibitor of poly(ADP-ribose) polymerase (PARP) activity. "
4.	Spermatic Cord Torsion (Testicular Torsion) 05/01/2003 - "One group served to determine baseline values of biochemical parameters, 1 that underwent sham operation served as a control, 1 underwent 2 hours of testicular torsion and 4 hours of detorsion, 2 received pretreatment with vehicle (saline or dimethyl sulfoxide) before detorsion and 4 received pretreatment with the poly (ADP-ribose) polymerase inhibitor nicotinamide, 3-aminobenzamide, 1,5-dihydroxyisoquinoline or 4-amino-1,8-naphthalimide before detorsion. "
5.	Neoplasm Metastasis (Metastasis) 06/01/2011 - "In this paper, an animal model of hepatic adenocarcinoma is used in demonstrating successful targeting of spleen metastases with generation 3 polyamidoamine 4-amino-1,8-naphthalimide dendrimer containing 8 europium ions (Eu-G3P4A18N) for luminescence imaging."

Related Drugs and Biologics

1.	Poly (ADP-Ribose) Polymerase-1
2.	Drinking Water
3.	Caspase 3 (Caspase-3)
4.	Dendrimers (Dendrons)
5.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
6.	Niacinamide (Nicotinamide)
7.	Ions
8.	Fluorides
9.	Europium
10.	Dimethyl Sulfoxide (DMSO)