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5- acetylneuraminyl- (2- 3)- galactosyl- (1- 4)- (fucopyranosyl- (1- 3))- N- acetylglucosamine (sialyl Lewis x)

Subscribe to New Research on 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine

is a ligand for L-selectin on the surface of high endothelial venules (HEVs) in mammalian lymphoid tissue

Also Known As:

sialyl Lewis x; NAG-1,4-F-1,3-GN; Neu5Ac-2-3-Gal-1-4-(Fuc-1-3)-GlcNAc; SLe(x); SLe(x)-OS; alpha-Neu5Ac-(2-3)-beta-D-Gal-(1-4)-(alpha-L-Fuc-(1-3))-beta-D-GlcNAc; sialyl Le(x); sialyl Lewis(x) tetrasaccharide; sialyl-Lex

Networked: 531 relevant articles (10 outcomes, 67 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 4088
- Polysaccharides: 2929
  - Oligosaccharides: 1372
    - 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine: 531

Experts

1.	Kannagi, Reiji: 14 articles (05/2012 - 10/2002)
2.	Ayabe, H: 12 articles (09/2002 - 04/2000)
3.	Sawai, T: 12 articles (09/2002 - 04/2000)
4.	Nakagoe, T: 12 articles (09/2002 - 04/2000)
5.	Tsuji, T: 11 articles (09/2002 - 04/2000)
6.	Yamaguchi, H: 11 articles (09/2002 - 04/2000)
7.	Yasutake, T: 11 articles (09/2002 - 04/2000)
8.	Nanashima, A: 11 articles (09/2002 - 04/2000)
9.	Reis, Celso A: 9 articles (01/2015 - 11/2004)
10.	Jibiki, M: 9 articles (09/2002 - 04/2000)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2002 - "When these cells were injected into the tail vein of nude mice, cells expressing moderate amounts of sialyl Lewis x (MeWo-FTIII.M) produced a significantly greater number of lung tumor foci than did parental MeWo cells. " 01/01/2012 - "We then correlated sialyl Le(X) expression of 215 UICC stage III and IV patients with disease-free and cancer-related survival. " 10/15/1993 - "The aim of the study was to elucidate whether sialyl Lex expression in tumors was correlated with patient survival. " 09/01/2015 - "Most PDAC tissues stained for SLe(x) and SLe(a) and tended to be expressed in the tumor samples with a higher presence of inflammatory immune cells. " 05/01/2015 - "We used a method called motif profiling to predict that a structural isomer of sLeA called sialyl-Lewis X (sLeX) is elevated in the plasma of some sLeA-low cancers. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 05/01/1991 - "Lex and sialyl Lex-i antigens have been regarded as pancreatic cancer-associated antigens, however, this study suggests that Lex and sialyl Lex-i are more useful markers for CIBD than CPH. " 05/01/2015 - "Glycan motif profiling reveals plasma sialyl-lewis x elevations in pancreatic cancers that are negative for sialyl-lewis A." 02/01/1996 - "Expression of sLe(x) and sLe(a) were associated with several clinicopathologic features which reflect tumor aggressiveness in esophageal, gastric and colorectal cancer, but not in pancreatic cancer. " 11/15/2000 - "Our study provides evidence that the expression level of FUT3 may regulate the expression of sialyl-Lewis a and sialyl-Lewis x surface antigens and consequently could play an important role in metastatic properties of human pancreatic cancer cells." 03/01/2000 - "This study provides evidence that the expression level of alpha(1,2) fucosyltransferase may regulate the expression of sialyl-Lewis a and sialyl-Lewis x antigens and consequently could play an important role in metastatic properties of human pancreatic cancer cells."
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2003 - "The aim of this study was to investigate whether or not a correlation exists between pre-operative levels of ganglioside serum sLe(x) and disease-free interval and survival in colorectal cancer patients. " 01/01/2012 - "The aim of this study was to establish a simple sialyl Le(X) staining score and to determine a potential correlation with the prognosis in a series of advanced colorectal carcinoma patients. " 01/01/2012 - "Our highly standardized and easy-to-use staining score is suitable for routine use and hence it could be recommended to evaluate sialyl Le(X)-expression as part of the standard histopathological analysis of colorectal carcinomas and to validate the score prospectively based on a larger population." 01/01/2012 - "Evidence exists that sialyl Le(X) expression is correlated with an unfavorable outcome in colorectal cancer. " 01/01/2012 - "A novel sialyl Le(X) expression score as a potential prognostic tool in colorectal cancer."
4.	Neoplasm Metastasis (Metastasis) 12/01/1993 - "Sialyl Lea and sialyl Lex showed strong expressions in the liver metastases, significantly greater than in the primary lesions. " 06/01/2006 - "Since some of the factors, such as sLe(x), 14-3-3sigma, cyclinD1 and Rb, showed different levels of expression in the pair, these cultured cells might be meaningful tools for clarification of distant metastasis in canine mammary gland tumours." 11/10/2005 - "However, the number of lung metastases was significantly increased in the group inoculated with the sLe(x)-negative variant (p = 0.0031), indicating that negative selection for the sLe(x) epitope resulted in enrichment for a subpopulation of cells with a high metastatic phenotype. " 11/10/2005 - "Mice inoculated in the mammary fat pad with sLe(x)-negative and -positive variants produced lung metastases. " 05/01/2003 - "We evaluated the role of sialyl Lewis X in liver metastasis in view of liver-associated immunity. "
5.	Hepatocellular Carcinoma (Hepatoma) 03/25/2013 - "The NFI thus obtained exhibits an intense response to sialyl Lewis X tetrasaccharide, which is overexpressed in human hepatocellular carcinoma cell lines. " 04/01/2004 - "The first fluorescent diboronic acid sensor specific for hepatocellular carcinoma cells expressing sialyl Lewis X." 01/01/2002 - "The Sialyl Lewis X expression in hepatocarcinogenesis: potential predictor for the emergence of hepatocellular carcinoma." 11/01/1995 - "Expression of sialyl Lewis(x) in hepatocellular carcinoma." 11/01/1995 - "These results lead us to speculate that the diminishing change of hepatocellular sialyl Lewis(x) expression with malignant transformation, or the small amounts of hepatocellular sialyl Lewis(x) expression in cancerous regions, are related to tumor spread of hepatocellular carcinoma."

Related Drugs and Biologics

1.	P-Selectin
2.	5- acetylneuraminyl- 2- 3- galactosyl- 1- 3- (fucopyranosyl- 1- 4)- N- acetylglucosamine
3.	Oligosaccharides
4.	Polysaccharides
5.	Fucose
6.	Complement System Proteins (Complement)
7.	Adenocarcinoma of lung
8.	Antigens
9.	5- acetylneuraminyl- (2- 3)- galactosyl- (1- 4)- (fucopyranosyl- (1- 3))- N- acetylglucosamine (sialyl Lewis x)
10.	E-Selectin

Related Therapies and Procedures

1.	Angioplasty (Angioplasty, Transluminal)
2.	Drug Therapy (Chemotherapy)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Microbubbles
5.	Radical Mastectomy