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Ro 24-5531
Also Known As:
1,25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol; Ro-24-5531; Ro24-5531
Networked:
8
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Secosteroids: 22
Vitamin D: 33265
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
Ro 24-5531: 8
Cholestanes
Sterols: 2245
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
Ro 24-5531: 8
Cholestenes
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
Ro 24-5531: 8
Lipids: 114793
Membrane Lipids: 1591
Sterols: 2245
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
Ro 24-5531: 8
Experts
1.
Mehta, Rajendra G.
: 1 article (05/2002)
2.
Mehta, Rajeshwari R.
: 1 article (05/2002)
Related Diseases
1.
Neoplasms (Cancer)
07/15/1995 - "
Although there was also a trend for dietary RO24-5531 supplementation during the postinitiation arm of this study to reduce the incidence of colon tumors, this did not reach statistical significance (P > 0.05).
"
07/15/1995 - "
The results of these studies demonstrated that dietary RO24-5531 supplementation during the initiation arm of these experiments significantly reduced (by 70%) the incidence of AOM-induced colonic tumors compared to rats on the standard diet without RO24-5531.
"
04/01/1994 - "
Ro24-5531 significantly extended tumor latency and lessened tumor incidence as well as tumor number in rats treated with the lower dose of NMU.
"
04/01/1994 - "
In rats treated with the higher dose of NMU, Ro24-5531 was fed in combination with tamoxifen; in these experiments, Ro24-5531 significantly enhanced the ability of tamoxifen to reduce total tumor burden, as well as to increase the probability that an animal would be tumor free at the end of the experiment.
"
05/01/2002 - "
Among these analogs, relatively less toxic but highly efficacious analogs, EB1089, RO24-5531, 1alpha-hydroxyvitamin D5 and a few others have been evaluated in a preclinical toxicity and in Phase I clinical trials for dose tolerance in advanced cancer patients.
"
2.
Carcinogenesis
07/15/1995 - "
These studies, therefore, demonstrate for the first time that supplemental dietary RO24-5531 is a chemopreventive agent in the AOM model of experimental colonic carcinogenesis.
"
01/01/1999 - "
We describe the development of a new system for quantitating the process of prostatic carcinogenesis in an experimental animal, and the use of this system to demonstrate that the retinoid, 4-hydroxyphenylretinamide, the deltanoid, Ro24-5531, and the estrogen analog, tamoxifen, all are effective agents for prevention of experimental prostate cancer.
"
3.
Carcinoma (Carcinomatosis)
07/01/1996 - "
Moreover, the ability of RO24-5531 to block the changes in PKC-zeta induced by AOM, as well as to up-regulate PKC-epsilon, may underlie its ability to prevent adenomas from progressing to carcinomas.
"
12/01/1995 - "
Chemopreventive activity of tamoxifen, N-(4-hydroxyphenyl)retinamide, and the vitamin D analogue Ro24-5531 for androgen-promoted carcinomas of the rat seminal vesicle and prostate.
"
4.
Breast Neoplasms (Breast Cancer)
04/01/1994 - "
In vitro, Ro24-5531 was 10-100 times more potent than 1,25-dihydroxyvitamin D3 for inhibition of proliferation of human breast cancer cell lines as well as primary cultures of cells from 2 patients with acute myelogenous leukemia.
"
05/01/1998 - "
The antiproliferative effect of 1,25-dihydroxycholecalciferol (Ro 21-5535) and of the two non hypercalcemic analogs (1a,25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol+ ++, Ro 24-5531 and 1a,25-dihydroxy-16-ene-23-yne-26,27-hexafluoro-19-nor-cholec alciferol, Ro 25-6760) was studied in MCF-7 and MDAMB-468 human breast cancer cell lines.
"
5.
Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
04/01/1994 - "
In vitro, Ro24-5531 was 10-100 times more potent than 1,25-dihydroxyvitamin D3 for inhibition of proliferation of human breast cancer cell lines as well as primary cultures of cells from 2 patients with acute myelogenous leukemia.
"
Related Drugs and Biologics
1.
1-hydroxyvitamin D5
2.
seocalcitol
3.
Tamoxifen
4.
Fenretinide
5.
Calcitriol (Calcijex)
6.
Protein Kinase C-epsilon
7.
Estradiol Congeners (Synthetic Estrogens)
8.
Vitamin D
9.
Retinoids
10.
Carcinogens