chitotriosidase

05/01/2014 - "The frequency of the 24 bp duplication was remarkably high in both Korean patients with Gaucher disease and in the normal population, limiting the efficacy of chitotriosidase as a biomarker in Gaucher disease in Korea. "
05/01/2014 - "Two patients with Gaucher disease (13.3%) had normal plasma chitotriosidase activity, and carried a homozygous 24 bp duplication of exon 10 of the CHIT1 gene. "
05/01/2014 - "However, homozygous duplication of a 24 bp region in exon 10 of the chitotriosidase gene (CHIT1) abolishes enzyme activity, limiting its use as a biomarker in Gaucher disease. "
05/01/2014 - "Plasma chitotriosidase activity is used for diagnosis and monitoring of Gaucher disease. "
01/01/2014 - "Although, about 6% of Caucasians have enzyme deficiency due to homozygosity of 24-bp duplication mutation in the chitotriosidase gene, it is currently established as a screening marker and therapeutic monitor for Gaucher's disease. "

01/01/2013 - "The aims of this study were to evaluate the sensitivity and specificity of chitotriosidase in a population of 232 sarcoidosis patients under the observation of our Sarcoidosis Regional Referral Centre in Siena and to analyse enzyme concentrations in different disease phenotypes (as defined by the recently published COS classification) to define its prognostic value. "
01/01/2009 - "In this study, we evaluate whether determining chitotriosidase in serum would be useful in the diagnosis and clinical management of patients with sarcoidosis. "
01/01/2008 - "The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients followed at the Sarcoidosis Regional Centre in Siena and to analyse chitotriosidase and sIL-2R concentrations in serum of these patients in order to understand their potential as disease markers. "
10/01/2007 - "In this study serum chitotriosidase levels were significantly higher in active sarcoidosis, than in inactive disease or healthy controls. "
10/01/2007 - "In this study, serum chitotriosidase levels were significantly higher in active sarcoidosis than in inactive disease or healthy controls. "

04/01/2001 - "The aim of this study is to elucidate the possible mechanisms underlying chitotriosidase overproduction in beta-thalassemia major. "
01/01/2014 - "Serum YKL-40 levels and chitotriosidase activity in patients with beta-thalassemia major."
04/01/2003 - "Plasma chitotriosidase activity in patients with beta-thalassemia."
09/01/2002 - "We measured plasma chitotriosidase levels in Israeli patients with beta-thalassemia to ascertain its use as a universal marker of disease and/or response to therapy. "
09/01/2002 - "Variable increases in chitotriosidase levels have been reported in Italian patients with beta-thalassemia major and intermedia. "

01/01/2012 - "Efficacy of serum chitotriosidase activity in early treatment of patients with active tuberculosis and a negative sputum smear."
11/01/2015 - "In this study, we explored whether chitotriosidase could be adopted as a biomarker to evaluate the curative effect on tuberculosis (TB). "
11/01/2015 - "The relationship between chitotriosidase activity and tuberculosis."
01/01/2012 - "In patients with active tuberculosis and a negative sputum smear for acid-fast bacillus, plasma chitotriosidase activity seems to be a strong marker for diagnosis of active disease which can be used while awaiting culture results."
01/01/2012 - "We investigated whether plasma chitotriosidase activity is a strong marker for early diagnosis of tuberculosis in patients for whom a bacillus smear is negative and tuberculosis culture is positive. "

09/01/2014 - "Role of changes in serum chitotriosidase activity in mice under conditions of hyperlipidemia and lipid-lowering effect of carboxymethylated (1-3)-β-D-glycan."
12/01/2006 - "Furthermore, animals fed t10,c12-CLA had pronounced hyperlipidemia, higher 8-iso-prostaglandin F(2alpha) levels, higher vulnerable atherosclerotic plaque with a lower smooth muscle and fibre contents and higher macrophage content and activation, assayed as plasma chitotriosidase compared to the control or c9,t11-CLA dietary groups. "
09/01/2014 - "The relationship between changes in chitotriosidase activity with atherogenic fractions and subfractions of serum lipoproteins during lipemia is discussed. "
04/01/2001 - "To evaluate (1) if lipid-lowering treatment could modify serum chitotriosidase activity and (2) be useful in monitoring lipid-lowering treatment, we have analyzed this enzyme activity in the participants in the Atozvastatin Versus Bezafibrate in Mixed Hyperlipidemia (ATOMIX) study, a double-blind, comparative, and randomized study comparing the efficacy of atorvastatin and bezafibrate in mixed hyperlipidemia. "
09/01/2009 - "Activities of matrix metalloproteinases and chitotriosidase were measured in blood serum from male and female ICR mice with moderate hyperlipidemia receiving atorvastatin (75 mg/kg). "