thrombin receptor peptide SFLLRNP

a synthetic peptide that induces early events of T cell activation and synergizes with TCR cross-linking for CD69 expression & interleukin-2 production; thrombin receptor agonist; do not confuse with TRAP peptide

Also Known As:

Networked: 47 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Frelinger, Andrew L: 3 articles (12/2021 - 08/2015)
2.	Michelson, Alan D: 3 articles (12/2021 - 08/2015)
3.	Angiolillo, Dominick J: 2 articles (09/2022 - 08/2022)
4.	Bass, Theodore A: 2 articles (09/2022 - 08/2022)
5.	Been, Latonya: 2 articles (09/2022 - 08/2022)
6.	Franchi, Francesco: 2 articles (09/2022 - 08/2022)
7.	Galli, Mattia: 2 articles (09/2022 - 08/2022)
8.	Geisler, Tobias: 2 articles (09/2022 - 08/2022)
9.	Jaoude, Patrick Abou: 2 articles (09/2022 - 08/2022)
10.	Jennings, Lisa K: 2 articles (09/2022 - 08/2022)

Related Diseases

1.	Wounds and Injuries (Trauma) 01/01/2016 - "Platelets from healthy individuals were incubated with sera from trauma patients and their responsiveness to a thrombin receptor-activating peptide was measured using aggregometry. " 08/01/1992 - "A single (5.0 micrograms/wound) application of the thrombin receptor-activating peptide (P517-30) significantly increased wound breaking strength from Day 5 (31% over controls) to Day 12. " 12/01/2001 - "[An experimental study of the effects of thrombin receptor activating peptide (TP508) on healing of ischemic wound and flap survival in rats]." 10/08/2020 - "Their platelets have increased basal (TREM)-like transcript-1 expression, a leftward shift in the dose/response for a thrombin receptor-activating peptide, an increased maximum response to adenosine 5'-diphosphate and TxA2, and a greatly exaggerated response to penetrating injuries in vivo. " 12/01/2001 - "To investigate the effects of the thrombin receptor activating peptide (TP508) on healing of ischemic wound and flap survival in rats. "
2.	Ischemia 04/01/1995 - "In the present study, the influence of the thrombin receptor activating peptide, SFLLRNPNDKYEPF (SFLL), on intracellular Na+ ([Na+]i) and tissue lysophosphatidylcholine (LPC) content during ischemia was investigated in an isolated, blood-perfused rabbit papillary muscle preparation. " 10/01/2007 - "Platelet function in 136 patients undergoing elective surgery for subcritical limb ischemia or infrarenal abdominal aortic aneurysm repair was assessed by P-selectin expression and fibrinogen binding with and without adenosine diphosphate (ADP) stimulation, and aggregation mediated by thrombin receptor-activating peptide and arachidonic acid (AA). "
3.	Endotoxemia 11/01/2003 - "As little is known about the in vivo regulation of PAR1, this study aimed to characterize the effects of systemic thrombin formation during human endotoxemia on the regulation of PAR1 and the associated responsiveness of human platelets to thrombin receptor activating peptide (TRAP). "
4.	Glioblastoma (Glioblastoma Multiforme) 03/09/1998 - "The presence of the tethered ligand thrombin receptor PAR1 (protease-activated receptor 1) in these cells was demonstrated at the level of receptor binding by using immunofluorescence studies with the monoclonal anti-PAR1 antibody Mab 31-2. Stimulation of human glioblastoma cells both with alpha-thrombin and the thrombin receptor activating peptide TRAP-6 resulted in a series of [Ca+]i spikes as shown by confocal laser fluorescence microscopy with fluo-3 as calcium sensitive fluorescence indicator. "
5.	Ischemic Stroke 01/01/2012 - "The aim of this study was to evaluate the reactivity of platelets in response to stimulation with thrombin receptor-activating peptide (TRAP) at 1, 10 and 90 days after ischaemic stroke and to compare it with results obtained in control groups. "

Related Drugs and Biologics

1.	Thrombin
2.	Thrombin Receptors (Thrombin Receptor)
3.	Ligands
4.	PAR-1 Receptor
5.	Lysophosphatidylcholines (Lysophosphatidylcholine)
6.	Indicators and Reagents (Reagents)
7.	Calcium
8.	rusalatide acetate (Chrysalin)
9.	thrombin receptor peptide (42-47)
10.	thrombin receptor peptide (42-55)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Therapeutics
3.	Artificial Respiration (Mechanical Ventilation)
4.	Ligation
5.	Injections