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zinc-desferrioxamine

inhibits the generation of hydroxy radicals during reperfusion of cat retina

Also Known As:

Zn-DFO

Networked: 12 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Chevion, Mordechai: 5 articles (10/2011 - 07/2003)
2.	Banin, Eyal: 3 articles (10/2011 - 07/2003)
3.	Berenshtein, Eduard: 3 articles (10/2011 - 07/2003)
4.	Obolensky, Alexey: 3 articles (10/2011 - 07/2003)
5.	Beiran, Itzchak: 2 articles (03/2007 - 03/2007)
6.	Dovrat, Ahuva: 2 articles (03/2007 - 03/2007)
7.	Schaal, Shlomit: 2 articles (03/2007 - 03/2007)
8.	Morad, Yair: 2 articles (05/2005 - 07/2003)
9.	Agarwal, Tushar: 1 article (03/2018)
10.	Kaur, Manpreet: 1 article (03/2018)

Related Diseases

1.	Parasitemia 08/01/1995 - "The results indicate that Zn-DFO is superior to DFO, especially at concentrations below 20 microM, as shown by decreased levels of hypoxanthine incorporation, lower levels of parasitemia, and interference with the life cycle of the parasite. "
2.	Wounds and Injuries (Trauma) 07/01/2003 - "It is suggested that Zn/DFO or Ga/DFO, by virtue of their enhanced ability to infiltrate cells and inhibit transition metal-dependent formation of free radicals through the combined push-pull mechanism, be considered as a basis for treatment of mustard injuries." 05/01/2005 - "The findings suggest that the combination of topically applied Zn/DFO and dexamethasone, by virtue of their additive inhibitory effects on free radical formation and inflammation, should be considered as a basis for the treatment of ocular mustard gas injuries." 08/01/2001 - "Since zinc desferrioxamine (Zn-DFO) has been shown to be a very potent protector against injuries induced by redox-active metal ions, we examined its protective effect against radiation-induced toxicity. " 03/01/1998 - "Zinc-desferrioxamine (Zn-DFO) was recently reported to be a very potent protector against the injuries induced by such metal ions in the vicinity of sensitive cellular targets. "
3.	Inflammation (Inflammations) 07/01/2003 - "Treatment with either Zn/DFO or Ga/DFO yielded marked protection (52%-64%), including faster healing of corneal epithelial erosions, less scarring and neovascularization, decreased inflammation in the anterior chamber, better maintenance of intraocular pressure, and less severe changes in the iris and lens. " 05/01/2005 - "The findings suggest that the combination of topically applied Zn/DFO and dexamethasone, by virtue of their additive inhibitory effects on free radical formation and inflammation, should be considered as a basis for the treatment of ocular mustard gas injuries." 03/01/2018 - "Various experimental treatments that aim to promote wound healing and minimize inflammation are being evaluated such as human mesenchymal and adipose stem cells, beta-1,3 glucan, angiotensin-converting enzyme inhibitors, cultivated fibroblasts, zinc desferrioxamine, antifibrinolytic agents, antioxidants, collagen cross-linking, and inhibitors of corneal neovascularization."
4.	Cataract (Cataracts) 03/01/2007 - "These results indicate a possible role for Zn-DFO in the prevention of cataracts." 12/01/2007 - "Therefore, the measure of decreasing oxygen concentration and the treatment of Zinc-desferrioxamine may reduce the incidence of cataract, which provides a new way for the prevention and treatment of cataract after vitrectomy." 03/01/2007 - "The present results may indicate a possible future role for Zn-DFO as a protective agent against oxygen-induced human cataract formation."
5.	Corneal Neovascularization 05/01/2005 - "In combination-treated eyes, corneal re-epithelization was faster, corneal neovascularization was less severe, and intraocular pressure was not as severely elevated as in the saline or the Zn/DFO- or dexamethasone-alone groups. " 03/01/2018 - "Various experimental treatments that aim to promote wound healing and minimize inflammation are being evaluated such as human mesenchymal and adipose stem cells, beta-1,3 glucan, angiotensin-converting enzyme inhibitors, cultivated fibroblasts, zinc desferrioxamine, antifibrinolytic agents, antioxidants, collagen cross-linking, and inhibitors of corneal neovascularization."

Related Drugs and Biologics

1.	Hypoxanthine
2.	zinc-desferrioxamine
3.	Metals
4.	Oxygen (Dioxygen)
5.	Ions
6.	Free Radicals
7.	Protective Agents
8.	Hydroxyl Radical
9.	Interleukin-6 (Interleukin 6)
10.	Mustard Gas (Sulfur Mustard)

Related Therapies and Procedures

1.	Vitrectomy