8- amino- 1,3- bis(cyclopropylmethyl)xanthine

a selective type IV phosphodiesterase inhibitor; structure given in first source

Also Known As:

BRL 61063; BRL-61063; BRL61063; 1H-Purine-2,6-dione, 8-amino-1,3-bis(cyclopropylmethyl)-3,7-dihydro-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Intracranial Vasospasm 02/01/1997 - "In contrast, prolonged treatment with BRL 61063 failed to alter the development of basilar spasm in the two hemorrhage canine models of chronic cerebral vasospasm. "
2.	Spasm (Spasms) 02/01/1997 - "In contrast, prolonged treatment with BRL 61063 failed to alter the development of basilar spasm in the two hemorrhage canine models of chronic cerebral vasospasm. "
3.	Septic Shock (Toxic Shock Syndrome) 12/01/1994 - "Beneficial effects of the phosphodiesterase inhibitors BRL 61063, pentoxifylline, and rolipram in a murine model of endotoxin shock."
4.	Infections 01/06/1995 - "Treatment with either BRL 61063 or pentoxifylline had little or no effect on the Poly I:C-induced candidacidal activity of BAL cells indicating that these compounds are unlikely to compromise non-specific host defense against infection."
5.	Hemorrhage 02/01/1997 - "In contrast, prolonged treatment with BRL 61063 failed to alter the development of basilar spasm in the two hemorrhage canine models of chronic cerebral vasospasm. "

1.	Pentoxifylline (Trental)
2.	Rolipram
3.	Poly I-C
4.	Phosphodiesterase Inhibitors