polyhemoglobin-superoxide dismutase-catalase

intermolecularly cross-linked hemoglobin, superoxide dismutase and catalase; prevents methemoglobin formation and iron release

Also Known As:

polyHb-SOD-CAT; polyHb-SOD-catalase

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Superoxide Dismutase: 11100
      - polyhemoglobin-superoxide dismutase-catalase: 5
    - Peroxidases: 304
      - Catalase: 7549
        polyhemoglobin-superoxide dismutase-catalase: 5
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - polyhemoglobin-superoxide dismutase-catalase: 5
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        polyhemoglobin-superoxide dismutase-catalase: 5

Experts

1.	Bae, J H: 1 article (09/2004)
2.	Chang, E J: 1 article (09/2004)
3.	Cho, K B: 1 article (09/2004)
4.	Hwang, J S: 1 article (09/2004)
5.	Kim, H C: 1 article (09/2004)
6.	Kim, S P: 1 article (09/2004)
7.	Lee, T H: 1 article (09/2004)
8.	Mun, K C: 1 article (09/2004)
9.	Suh, S I: 1 article (09/2004)
10.	Chang, Thomas M S: 1 article (01/2002)

Related Diseases

1.	Ischemia 01/01/1997 - "These preliminary results show that perfusion with PolyHb-SOD-CAT may alleviate oxidative stress in a model of ischemia-reperfusion." 09/01/2004 - "Normal male Sprague-Dawley rats were divided into 6 groups: the sham-operated control group, the group treated with polyHb,and the group treated with polyHb-SOD-catalase (PSC) (per groups were subjected to ischemia for 1 hour or 2 hours). " 07/01/1998 - "PolyHb-SOD-CAT decreases the formation of oxygen radicals compared with PolyHb in a rat intestinal ischemia-reperfusion model." 01/01/1997 - "This is used to compare the effects of crosslinked hemoglobin (PolyHb) versus crosslinked hemolobin-superoxide dismutase-catalase (PolyHb-SOD-CAT) on free radical generation in ischemia-reperfusion. " 01/01/1997 - "The effects of PolyHb (intermolecularly crosslinked hemoglobin) and PolyHb-SOD-CAT (intermolecularly crosslinked hemoglobin, superoxide dismutase and catalase) on the production of hydroxyl radical was studied using a rat hindlimb model of ischemia-reperfusion. "
2.	Reperfusion Injury 01/01/1997 - "Since free radicals may play a major role in the pathogenesis of ischemia-reperfusion injury, this suggests a role for PolyHb-SOD-CAT as a possible protective perfusate in intestinal reperfusion injury." 01/01/2002 - "The results show that the cross-linked PolyHb-SOD-CAT solution, unlike the other solutions, can supply oxygen to ischemic tissues without causing reperfusion injury in the transient global brain ischemia-reperfusion model."
3.	Brain Ischemia (Cerebral Ischemia) 01/01/2002 - "Cross-linked polyhemoglobin-superoxide dismutase-catalase supplies oxygen without causing blood-brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion." 01/01/2002 - "The results show that the cross-linked PolyHb-SOD-CAT solution, unlike the other solutions, can supply oxygen to ischemic tissues without causing reperfusion injury in the transient global brain ischemia-reperfusion model."
4.	Brain Edema (Cerebral Edema) 01/01/2002 - "Cross-linked polyhemoglobin-superoxide dismutase-catalase supplies oxygen without causing blood-brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion."

Related Drugs and Biologics

1.	Superoxide Dismutase
2.	Hemoglobins (Hemoglobin)
3.	Catalase
4.	Hydroxyl Radical
5.	Reactive Oxygen Species (Oxygen Radicals)
6.	Solutions
7.	Oxygen (Dioxygen)
8.	Free Radicals
9.	salicylhydroxamic acid (SHAM)