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SK&F 107647

a synthetic hematoregulatory peptide that shares biological and/or modulatory activities with natural hematopoetic cytokines

Also Known As:

SK&F-107647

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - SK&F 107647: 6

Experts

1.	Balcarek, J: 1 article (04/2000)
2.	Bhatnagar, P K: 1 article (04/2000)
3.	Boppana, V K: 1 article (04/2000)
4.	Citerone, D R: 1 article (04/2000)
5.	Cowley, H C: 1 article (04/2000)
6.	Davis, C B: 1 article (04/2000)
7.	DeMarsh, P L: 1 article (04/2000)
8.	Frey, C L: 1 article (04/2000)
9.	Harris, R Z: 1 article (04/2000)
10.	Johanson, K: 1 article (04/2000)

Related Diseases

1.	Infections 01/01/1996 - "Thus, the hematoregulatory activities of SK&F 107647 can increase natural host resistance to infections caused by both gram-negative and gram-positive bacteria." 05/01/1994 - "The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. " 05/01/1994 - "Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systemic Candida albicans infections in normal and immunosuppressed mice." 09/01/1999 - "The effects of the hematoregulatory peptide SK&F 107647 were examined in a persistently and profoundly neutropenic rabbit model of disseminated candidiasis in order to determine its potential to enhance resistance against infection and its role as an adjunct to conventional antifungal chemotherapy. "
2.	Neoplasms (Cancer) 05/01/1996 - "To study the pharmacokinetics of SK&F 107647, a novel hematoregulatory agent, in rats, dogs, and patients with non-lymphoid solid tumor malignancy. " 04/01/2000 - "Volunteers received SK&F 107647 as single 15-minute iv infusion doses of 1, 10, 100, 500, and 1,000 microg/kg. Cancer patients received 2-hour iv infusions of 0.001, 0.01, 0.1 and 1 microg/kg once daily for 10 days. "
3.	Sepsis (Septicemia) 01/01/1996 - "Treatment of experimental gram-negative and gram-positive bacterial sepsis with the hematoregulatory peptide SK&F 107647." 01/01/1996 - "To determine if the hematoregulatory activities of SK&F 107647 could offer protection over conventional antibiotic therapy or as a single agent in animal models of bacterial sepsis, rats were implanted intraperitoneally with a live bacteria-containing fibrin-thrombin clot. "
4.	Virus Diseases (Viral Diseases) 01/01/1996 - "SK&F 107647, a novel synthetic low-molecular-weight peptide, has demonstrated potent antiinfective activities in murine models of fungal and viral infection. "
5.	Mycoses (Diseases, Fungus) 04/01/2000 - "SK&F 107647, a previously described synthetic immunomodulatory peptide, indirectly stimulates bone marrow progenitor cells and phagocytic cells, and enhances host defense effector mechanisms in bacterial and fungal infection models in vivo. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Thrombin
3.	Fibrin
4.	Anti-Bacterial Agents (Antibiotics)
5.	Amphotericin B (Amphotericin)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)