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7-hydroxycholesteryl-3-oleate

Also Known As:

7 beta-hydroxycholesteryl-3-oleate; 7-OH-cholesteryl-3-oleate

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Neoplasms (Cancer) 02/15/1994 - "When C6 cells and 7 beta-hydroxycholesteryl-3-oleate were simultaneously injected, tumors did not develop in 80% of the animals. " 02/15/1994 - "The injection of liposomes without oxysterol had no effect on tumor growth, whereas injection of liposomes containing 7 beta-hydroxycholesteryl-3-oleate (36 nmol) gave rise to a marked decrease in tumor volume (from 4.4 +/- 1.0 to 0.7 +/- 0.4 mm3). "
2.	Gliosis 05/01/1995 - "In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the influence of 7 beta-hydroxycholesteryl-3-oleate (oxysterol) on the intensity of the astrocytic reaction and the axonal regeneration. " 12/01/1992 - "Liposomes containing 3 nmol of either 7 beta-hydroxycholesterol, 7 beta-hydroxycholesteryl-3-stearate or 7 beta-hydroxycholesteryl-3-oleate reduced by about 50% the intensity of the reactive gliosis in the frontal cortex of six-day-old rats and by 40% the number of dividing astrocytes. "
3.	Spinal Cord Injuries (Spinal Cord Injury) 05/01/1995 - "These results demonstrate that 7 beta-hydroxycholesteryl-3-oleate can reduce the astrocytic reaction following spinal cord injury, promoting the serotonergic reinnervation of a denervated territory."
4.	Glioblastoma (Glioblastoma Multiforme) 02/15/1994 - "The effect of 7 beta-hydroxycholesteryl-3-oleate on rat brain C6 glioblastoma cells was studied. " 02/15/1994 - "Local administration of 7 beta-hydroxycholesteryl-3-oleate inhibits growth of experimental rat C6 glioblastoma." 02/15/1994 - "Taken together, these data suggest that 7 beta-hydroxycholesteryl-3-oleate might be useful for local glioblastoma chemotherapy."

Related Drugs and Biologics

1.	Oxysterols
2.	Liposomes (Liposome)
3.	cholest-5-en-3 beta,7 alpha-diol

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)