HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
SB 201823-A
structure in first source
Also Known As:
4-(2-(3,4-dichlorophenoxy)ethyl)-1-pentylpiperidine; SB-201823-A
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperidines: 17
SB 201823-A: 1
Related Diseases
1.
Stroke (Strokes)
09/01/1995 - "
We evaluated the ability of a novel neuronal calcium channel blocker, SB 201823-A, to block central neuronal calcium influx in vitro and to reduce ischemic injury in two rodent models of focal stroke.
"
2.
Ischemia
09/01/1995 - "
In mice, treatments with 10 mg/kg IP SB 201823-A beginning 30 minutes after focal ischemia significantly reduced infarct volume by 41.5% (P < .01).
"
09/01/1995 - "
In rats, a single treatment with 10 mg/kg IV SB 201823-A beginning 30 minutes after focal ischemia decreased (P < .05) hemispheric infarct by 30.4% and infarct volume by 29.3% and reduced (P < .05) forelimb deficits by 47.8% and hindlimb deficits by 36.3%.
"
09/01/1995 - "
SB 201823-A antagonizes calcium currents in central neurons and reduces the effects of focal ischemia in rats and mice.
"
3.
Infarction (Infarctions)
09/01/1995 - "
In mice, treatments with 10 mg/kg IP SB 201823-A beginning 30 minutes after focal ischemia significantly reduced infarct volume by 41.5% (P < .01).
"
09/01/1995 - "
In rats, a single treatment with 10 mg/kg IV SB 201823-A beginning 30 minutes after focal ischemia decreased (P < .05) hemispheric infarct by 30.4% and infarct volume by 29.3% and reduced (P < .05) forelimb deficits by 47.8% and hindlimb deficits by 36.3%.
"
4.
Brain Ischemia (Cerebral Ischemia)
09/01/1995 - "
These results indicate that the new neuronal calcium channel blocker SB 201823-A can block stimulated calcium influx into central neurons and can provide neuroprotection in two models of focal cerebral ischemia without affecting blood pressure.
"
Related Drugs and Biologics
1.
Calcium Channel Blockers (Blockers, Calcium Channel)
2.
Calcium