zaleplon (Sonata)

an azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; a hypnotic with less marked effect on psychomotor functions compared to lorazepam

Also Known As:

Sonata; 3'-(3-cyanopyrazolo(1,5-alpha)pyrimidin-7-yl)-N-ethylacetanilide; CL 284,846; CL 284846; CL-284846; CL284,846; L 846; L-846; N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethylacetamide; SKP-1041; Starnoc; Zelepion; Acetamide, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethyl-

Networked: 196 relevant articles (19 outcomes, 39 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Engelhardt, Matthias: 3 articles (06/2022 - 08/2019)
2.	Pschadka, Gregor: 3 articles (06/2022 - 08/2019)
3.	Römer, Thomas: 3 articles (06/2022 - 01/2021)
4.	Schiermeier, Sven: 3 articles (06/2022 - 01/2021)
5.	Baglioni, Antonella: 3 articles (09/2019 - 09/2017)
6.	D'Alessandro, Patrizia: 3 articles (09/2019 - 09/2017)
7.	Elisei, Sandro: 3 articles (09/2019 - 09/2017)
8.	Piccirilli, Massimo: 3 articles (09/2019 - 09/2017)
9.	Roth, Thomas: 3 articles (01/2009 - 12/2000)
10.	Fenchel, M: 3 articles (05/2007 - 10/2003)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 01/01/2021 - "Linear mixed effects models demonstrated that 6 weeks of treatment with zaleplon significantly improved symptoms of both insomnia and depression. " 05/01/2000 - "These results show that zaleplon provides effective treatment of insomnia with a favourable safety profile." 02/01/2000 - ": Zaleplon 10 mg is effective in the treatment of sleep onset insomnia over a period of 35 nights, with minimal evidence of undesired effects." 08/01/1999 - "CONCLUSION: Zaleplon is effective in reducing latency to sleep without evidence of undesired effects in elderly patients with insomnia." 08/01/1999 - "Zaleplon is effective in the treatment of insomnia. "
2.	Leiomyoma (Uterine Fibroids) 01/01/2017 - "The Sonata System is a promising treatment modality for uterine fibroids. " 04/01/2022 - "The SONATA trial was a prospective multicenter interventional trial that assessed the safety and efficacy of TFA for treatment of women with symptomatic uterine fibroids. " 04/01/2022 - "Durable Improvement in Generic and Fibroid-Specific Quality of Life in Women Treated with Transcervical Fibroid Ablation with the Sonata System After Three Years." 01/01/2019 - "These results support the efficacy and safety of the Sonata system as a first-line treatment for women affected by symptomatic uterine fibroids." 10/01/2021 - "A subgroup of patients with submucous or large fibroids were analyzed from two prospective clinical trials (FAST-EU and SONATA) of sonography-guided TFA with the Sonata® system. "
3.	Epilepsy (Aura) 05/01/2010 - "This study measured the impact of Mozart's Sonata for two pianos in D major, K.448, on different epileptic foci of epileptiform discharge in Taiwanese children (n=58) with seizure disorders and investigated the characteristics of the musical stimulus presented that resulted in epileptiform discharge reduction. " 01/01/2023 - "In all, listening to music, let alone a specific kind of sonata, does not appear to have any beneficial effect on epilepsy. " 01/01/2023 - "In recent years, an ostensible Mozart effect, suggesting beneficial influences of listening to the sonata KV448 on epilepsy, has been extensively covered in popular media outlets. " 05/01/2018 - "To present a review of the so-called «Mozart effect», to explain why Mozart and his sonata K.448 were chosen, and to review the available literature on the treatment of epilepsy with that sonata. " 05/01/2018 - "[Epilepsy, Mozart and his sonata K.448: is the «Mozart effect» therapeutic?]"
4.	Memory Disorders (Memory Loss) 12/01/2000 - "In this study in 10 young, healthy volunteers, zaleplon was eliminated more rapidly, produced no memory loss, and caused less sedation than zolpidem at the same doses."
5.	Respiratory Insufficiency (Respiratory Failure) 01/01/2005 - "This improved risk profile includes: the effects of zaleplon on psychomotor and cognitive performance; tolerance, withdrawal and rebound; respiratory depression; sleep architecture; and other treatment-emergent adverse effects. "

Related Drugs and Biologics

1.	Zolpidem (Ambien)
2.	Hypnotics and Sedatives (Sedatives)
3.	Benzodiazepines
4.	Triazolam (Halcion)
5.	Therapeutic Uses
6.	Eszopiclone (Lunesta)
7.	zopiclone (Zop)
8.	Temazepam (Nocturne)
9.	Trazodone (Trittico)
10.	zaleplon (Sonata)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiofrequency Ablation
3.	Music Therapy
4.	Drug Therapy (Chemotherapy)
5.	Negative-Pressure Wound Therapy