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N-acetyl-S-(propionamide)cysteine

structure in first source

Also Known As:

N-APC; N-acetyl-S-(3-amino-3-oxopropyl)cysteine

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfur Amino Acids: 221
    - Cysteine: 6760
      - Acetylcysteine: 4440
        N-acetyl-S-(propionamide)cysteine: 10
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Sulfur Amino Acids: 221
    - Cysteine: 6760
      - Acetylcysteine: 4440
        N-acetyl-S-(propionamide)cysteine: 10

Experts

1.	Jacobsen, Anne Flem: 2 articles (09/2016 - 07/2011)
2.	Mowinckel, Marie-Christine: 2 articles (09/2016 - 07/2011)
3.	Sandset, Per Morten: 2 articles (09/2016 - 07/2011)
4.	Børresen-Dale, Anne-Lise: 1 article (09/2016)
5.	Garred, Øystein: 1 article (09/2016)
6.	Iversen, Nina: 1 article (09/2016)
7.	Kristensen, Vessela N: 1 article (09/2016)
8.	Sahlberg, Kristine Kleivi: 1 article (09/2016)
9.	Skretting, Grethe: 1 article (09/2016)
10.	Tinholt, Mari: 1 article (09/2016)

Related Diseases

1.	Activated Protein C Resistance (APC Resistance) 04/01/2002 - "To study this, recombinant FV mutants were reconstituted in FV-deficient plasma, after which normalized APC-sensitivity ratios (n-APC-SRs) were measured in activated partial thromboplastin time-based and Russell's Viper Venom time-based APC-resistance tests. " 03/01/1998 - "Using cutoff points derived from the normal PCR-screened population (n = 162), two assays for APC resistance (APC-SR and n-APC-SR) gave poor concordance with the PCR assay (sensitivity 29% and 57%, respectively). " 01/01/1996 - "Incomplete cosegregation of heterozygosity for the 1691 G-->A mutation with APC resistance (APC-SR < 2.4 or n-APC-SR < 0.75) was observed, showing that the functional assay alone is insufficient for a firm diagnosis. "
2.	Neoplasms (Cancer) 05/01/2009 - "Expressing a tumor-associated N-APC mutant in mammalian cells with an intact mitotic checkpoint produces premature anaphase onset with missegregated chromosomes." 05/01/2009 - "In this study, we report an interaction of tumor-associated N-terminal APC fragments (N-APC) with Mad2, an essential mitotic checkpoint protein, providing a direct molecular support for linking APC mutations to the generation of CIN. " 10/01/2014 - "We discovered that expression of tumor-associated N-terminal APC fragments (APC-N, APC-N1, APC-N2, and APC-N3, which contain amino acids 1-1018, 1-448, 449-781, and 782-1018 respectively), resulted in primary cilia defects. "
3.	Thrombosis (Thrombus) 09/01/1996 - "In a pilot study, 28 consecutive patients with thrombosis and 23 age and sex matched healthy normal controls were investigated with normalised APC sensitivity ratio (n-APC-SR) to know the defect exists and if so its prevalence in India. " 09/01/1998 - " Several of these effects of OCs were more pronounced in former thrombosis patients than in healthy women specifically on factor VII, antithrombin, n-APC-sr, and protein C. " 09/01/1998 - "In the former thrombosis patients several of these effects of oral contraceptives were more pronounced than in healthy women: specifically on factor VII, antithrombin, n-APC-sr and protein C. "
4.	Venous Thrombosis (Deep-Vein Thrombosis) 07/01/2011 - "Also in carriers of the F5 rs6025 polymorphism the risk for venous thrombosis was increased for women with higher n-aPC-sr. Our findings substantiate the importance of the aPC resistant phenotype as a risk factor for pregnancy-related venous thrombosis." 07/01/2011 - "Pregnant women and women using oral contraceptives and/or anticoagulants were excluded due to the effect on the n-aPC-sr. In women without the F5 rs6025 polymorphism, free tissue factor pathway inhibitor (TFPI), free protein S and protein C activity were associated with n-aPC-sr. Unadjusted odds ratio for venous thrombosis for women with n-aPC-sr in the 4th quartile as compared with n-aPC-sr below the 4th quartile was 2·4 (95% confidence interval 1·7-3·6). "
5.	Colonic Neoplasms (Colon Cancer) 05/01/2009 - "N-APC interacts with Mad2 in Xenopus egg extracts, colon cancer cells, and in vitro with purified components. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Protein C
3.	Protein S
4.	Oral Contraceptives
5.	Antithrombins
6.	lipoprotein-associated coagulation inhibitor (TFPI)
7.	von Willebrand Factor
8.	Hemostatics (Antihemorrhagics)
9.	Fibrinogen (Factor I)
10.	Factor VII (Proconvertin)