CP 122288
activates the trigeminovascular receptor blocking neurogenic inflammation within dura mater; a 5-HT1 receptor agonist
Also Known As:
CP-122,288; CP-122288; N-methyl-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole-5-methanesulfonamide; 1H-Indole-5-methanesulfonamide, N-methyl-3-((1-methyl-2-pyrrolidinyl)methyl)-, (R)-
Networked: 5
relevant articles (1 outcomes,
1 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
| 1. | Christianssen, I:
1 article
(02/2000)
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| 2. | Diener, H C:
1 article
(02/2000)
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| 3. | Ellis, P:
1 article
(02/2000)
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| 4. | Ferrari, M D:
1 article
(02/2000)
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| 5. | Hettiarachchi, J:
1 article
(02/2000)
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| 6. | Kleinermans, D:
1 article
(02/2000)
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| 7. | Kok, J G:
1 article
(02/2000)
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| 8. | Olesen, J:
1 article
(02/2000)
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| 9. | Poole, P H:
1 article
(02/2000)
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| 10. | Roon, K I:
1 article
(02/2000)
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Related Diseases
| 1. | Neurogenic Inflammation
02/01/2000
- " No acute antimigraine efficacy of CP-122,288, a highly potent inhibitor of neurogenic inflammation: results of two randomized, double-blind, placebo-controlled clinical trials." 11/01/1995
- " 7. These data demonstrate that in the rat, CP-122,288 is a highly potent and selective inhibitor of neurogenic inflammation in intracranial tissues, at doses which are devoid of vasoconstrictor activity in dog. " 11/01/1995
- " Interestingly, doses of CP-122,288 that inhibit neurogenic inflammation in rat dura mater (0.3-300 ng kg-1) were demonstrated to be devoid of vasoconstrictor activity in either the carotid or coronary vascular beds of dog. " 11/01/1995
- " The in vivo pharmacological profile of a 5-HT1 receptor agonist, CP-122,288, a selective inhibitor of neurogenic inflammation." 05/01/1995
- " These results suggest that CP-122,288 is a potent inhibitor of neurogenic inflammation in rat skin and that the effect may be due to a prejunctional inhibition of neuropeptide release."
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| 2. | Migraine Disorders (Migraine)
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| 3. | Headache (Headaches)
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