HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))

Subscribe to New Research on N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium

a neurotoxic quaternary haloperidol metabolite in rat liver; structure in first source

Also Known As:

HPP(+); BCPP(+); 4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)pyridinium; 4-CFOBP; N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium chloride; N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium iodide; N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium perchlorate

Networked: 329 relevant articles (9 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Whyte, Michael P: 17 articles (06/2015 - 06/2006)
2.	Millán, José Luis: 13 articles (12/2015 - 06/2008)
3.	Mumm, Steven: 12 articles (06/2015 - 06/2006)
4.	Narisawa, Sonoko: 6 articles (12/2015 - 06/2008)
5.	Shimada, Takashi: 6 articles (12/2015 - 01/2011)
6.	Mornet, Etienne: 6 articles (11/2015 - 01/2009)
7.	Coburn, Stephen P: 6 articles (06/2015 - 08/2007)
8.	Oda, Kimimitsu: 5 articles (08/2015 - 04/2012)
9.	Sohda, Miwa: 5 articles (08/2015 - 04/2012)
10.	Wenkert, Deborah: 5 articles (06/2015 - 08/2007)

Related Diseases

1.	Cysts 03/10/2011 - "Nothing is known on the efficacy of HPP on tapeworm cysts or eggs. " 02/01/2006 - "In this study, we examined the effects of high-pressure processing (HPP) on ground pork containing viable tissue cysts of the VEG strain of T. " 02/01/2006 - "Results indicate that HPP treatment of ground pork with 300 MPa of pressure will render tissue cysts of T. " 02/01/2006 - "Ground pork containing tissue cysts was exposed to 400, 300, 200, 100, or 0 MPa treatment for 30, 60, or 90 sec in a commercial HPP unit. " 09/01/1989 - "Microscopic examination revealed mucosal cysts (MC), focal foveolar hyperplasia (FFH), and hyperplastic polyp (HPP). "
2.	Craniosynostoses (Craniosynostosis) 05/01/2015 - "The authors discuss their case series of 4 HPP patients treated at their institution with ERT who have undergone successful surgical intervention for craniosynostosis. " 05/01/2015 - "Traditionally, HPP has had a poor prognosis, with few children surviving to exhibit the phenotype of clinical craniosynostosis that requires surgical intervention. " 05/01/2015 - "Patients with HPP have defective bone mineralization as well as craniosynostosis that can be seen in the infantile and childhood forms of this disease. " 01/01/2015 - "These results are very promising especially with regard to the skeletal phenotype but it is unclear whether ERT also has beneficial effects for craniosynostosis and in other affected tissues in HPP such as brain and kidney. " 10/01/2014 - "These findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP, including true bony craniosynostosis in the context of severely diminished bone mineralization. "
3.	Hypertension (High Blood Pressure) 03/24/2015 - "AASI, 24 hPP, sleeptime relative SBP decline and 24 hSBP are the most significant ambulatory blood pressure-related parameters in predicting renal impairment in resistant hypertension." 12/01/2013 - "He manifested HPP in childhood and in middle age received hemodialysis for CRF attributed to hypertension and anti-inflammatory medication. " 11/01/2012 - "For Chr 18, selected for the Russian part of C-HPP, about 25% of the encoded genes were associated with diseases, including cancers and neurodegenerative and psychiatric diseases, as well as type 1 diabetes and essential hypertension. " 11/01/1990 - "Monotherapy with HPP proved beneficial in affection of 1-2 joints whereas the baths appeared preferable in polyosteoarthrosis, its association with spinal osteoarthrosis, arterial hypertension. "
4.	Adenocarcinoma 06/01/1983 - "Consequently, the effect of Hx and HPP on the metabolism of [6-3H]-FUra was examined in 5 human colorectal adenocarcinomas maintained as xenografts in immune-deprived mice. " 01/01/2008 - "Immunohistochemistry and Western blot is used to analyse HIF-1alpha expression in normal colonic mucosa, hyperplastic polyps (HPP), sessile serrated adenomas (SSA), low-grade (TA-LGD) and high-grade (TA-HGD) traditional adenomas as well as in non-metastatic and metastatic colorectal adenocarcinomas. " 08/22/1996 - "The same concentration of antagonist abolished responses to PYY and [Leu31,Pro34]NPY but had no effect upon human pancreatic polypeptide (hPP) in monolayer cultures of the human adenocarcinoma cell line, Colony-6. Schild analysis of BIBP3226 antagonism of PYY responses in Colony-6 cells provided a pA2 value of 7.9 with a Hill slope of 1.03, indicating competitive antagonism at these epithelial Y1 receptors." 05/01/1982 - "A series of four human colon adenocarcinomas, growing as xenografts in immune-deprived mice, have been used to evaluate the efficacy of 5-FU in combination with two purines, hypoxanthine (Hx) and allopurinol (HPP), which have reduced the toxicity of 5-FU in host mice. "
5.	Congenital Abnormalities (Deformity) 09/01/2008 - "A boy with HPP showing long bone deformity that spontaneously improved in utero and after birth is described. " 09/01/2008 - "The patient is an autosomal recessive case of HPP with prenatal long bone deformity but with spontaneous prenatal and postnatal improvement. " 09/01/2008 - "Our objective was to identify TNSALP mutations and characterize the inheritance pattern of a family with clinically variable HPP with one child manifesting in utero with long bone deformity but showing spontaneous prenatal and postnatal improvement. " 11/28/1997 - "BPP displayed the highest frequency of associated congenital defects (23.4%, vs HPP:6.6%, FPP: 15.4%). " 10/01/2011 - "Clinical features of HPP include defective bone mineralisation with bone deformities, fractures and chronic non-bacterial osteomyelitis. "

Related Drugs and Biologics

1.	Allopurinol (Remid)
2.	Fluorouracil (Carac)
3.	Melphalan (Alkeran)
4.	Hypoxanthine
5.	1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)
6.	Vitamin E
7.	Purines
8.	Procarbazine (Matulane)
9.	Prednisolone (Predate)
10.	Hydrogen Peroxide (Hydroperoxide)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Baths
4.	Laparoscopic Cholecystectomy
5.	Enzyme Replacement Therapy