3-pyridyl pinacidil

RN refers to cpd without isomeric designation

Also Known As:

3-pyridyl pinacidil, (+)-isomer; 3-pyridyl pinacidil, (+-)-isomer; 3-pyridyl pinacidil, (-)-isomer; N''-cyano-N-3-pyridyl-N'-1,2,2-trimethylpropylguanidine

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - Pinacidil: 291
      - 3-pyridyl pinacidil: 1

Experts

1.	Das, B: 1 article (03/2003)
2.	Sarkar, C: 1 article (03/2003)

Related Diseases

1.	Coronary Occlusion 03/01/2003 - "Therefore, we may conclude that intervention by intravenous administration of nicorandil and 3-pyridyl pinacidil (through the selective activation of mitochondrial KATP channels), increases survival rate and exhibits antiarrhythmic and cardioprotective effects during coronary occlusion and reperfusion in anesthetized rabbits, when administered prior to and during coronary occlusion. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 03/01/2003 - "Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion."
3.	Myocardial Infarction 03/01/2003 - "In both Group I and Group II, early intravenous infusion of nicorandil (100 micrograms/kg bolus + 10 micrograms/kg/min), 3-pyridyl pinacidil (3.0 micrograms/kg bolus + 1.0 microgram/kg/min), HMR 1883 (3 mg/kg)/nicorandil and HMR 1883 (3 mg/kg)/3-pyridyl pinacidil, just prior to and during ischemia, increased survival rate (75%, 67%, 86% and 75% vs. 60% in the control subgroup in Group I; 67%, 75%, 75% and 67% vs. 43% in the control subgroup in Group II), significantly decreased the incidence and severity of life-threatening arrhythmias and significantly decreased myocardial infarct size. "
4.	Ischemia 03/01/2003 - "In both Group I and Group II, early intravenous infusion of nicorandil (100 micrograms/kg bolus + 10 micrograms/kg/min), 3-pyridyl pinacidil (3.0 micrograms/kg bolus + 1.0 microgram/kg/min), HMR 1883 (3 mg/kg)/nicorandil and HMR 1883 (3 mg/kg)/3-pyridyl pinacidil, just prior to and during ischemia, increased survival rate (75%, 67%, 86% and 75% vs. 60% in the control subgroup in Group I; 67%, 75%, 75% and 67% vs. 43% in the control subgroup in Group II), significantly decreased the incidence and severity of life-threatening arrhythmias and significantly decreased myocardial infarct size. "

Related Drugs and Biologics

1.	KATP Channels
2.	Pinacidil (Pindac)
3.	Nicorandil (SG 75)
4.	clamikalant

Related Therapies and Procedures

1.	Intravenous Administration
2.	Intravenous Infusions