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siratiazem
RN refers to (2S-cis)-isomer
Also Known As:
2,3-dihydro-3-acetoxy-2-(4-methoxyphenyl)-5-(2-(isopropyl(methyl)amino)ethyl)-1,5-benzothiazepin-4(5H)-one; 3-acetoxy-2,3-dihydro-5-(2-(N-isopropyl-N-methylamino)ethyl)-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-(5H)-one; LR A113; LR-A-113; LR-A113
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzazepines: 5
Diltiazem: 2789
siratiazem: 2
Related Diseases
1.
Ventricular Fibrillation
11/01/1993 - "
The incidence of ventricular fibrillation (VF) on reperfusion was significantly reduced by siratiazem at a concentration of 2 mg kg-1 only.
"
2.
Bradycardia
11/01/1993 - "
The antiarrhythmic effects of both diltiazem and siratiazem may be due in part to direct electrophysiologic effects on cardiac tissue to block sodium and calcium channels and in part to an antiischaemic effect associated with bradycardia and vasodepression.
"
3.
Hypoxia (Hypoxemia)
10/01/1995 - "
There was no significant difference in potency between siratiazem and diltiazem in the presence of normal physiological salt solution (IC25 for siratiazem 0.13 +/- 0.04 microM and for diltiazem 0.08 +/- 0.02 microM) or one mimicking some of the conditions that occur during myocardial ischaemia (hypoxia, acidosis, reduced glucose and addition of lactate).
"
4.
Acidosis
10/01/1995 - "
There was no significant difference in potency between siratiazem and diltiazem in the presence of normal physiological salt solution (IC25 for siratiazem 0.13 +/- 0.04 microM and for diltiazem 0.08 +/- 0.02 microM) or one mimicking some of the conditions that occur during myocardial ischaemia (hypoxia, acidosis, reduced glucose and addition of lactate).
"
Related Drugs and Biologics
1.
Diltiazem (Cardizem)
2.
Lactic Acid (Lactate)
3.
Calcium Channels (Calcium Channel)
4.
Solutions
5.
Sodium
6.
Salts
7.
Glucose (Dextrose)