siratiazem

RN refers to (2S-cis)-isomer

Also Known As:

2,3-dihydro-3-acetoxy-2-(4-methoxyphenyl)-5-(2-(isopropyl(methyl)amino)ethyl)-1,5-benzothiazepin-4(5H)-one; 3-acetoxy-2,3-dihydro-5-(2-(N-isopropyl-N-methylamino)ethyl)-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-(5H)-one; LR A113; LR-A-113; LR-A113

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Diltiazem: 2789
        siratiazem: 2

Related Diseases

1.	Ventricular Fibrillation 11/01/1993 - "The incidence of ventricular fibrillation (VF) on reperfusion was significantly reduced by siratiazem at a concentration of 2 mg kg-1 only. "
2.	Bradycardia 11/01/1993 - "The antiarrhythmic effects of both diltiazem and siratiazem may be due in part to direct electrophysiologic effects on cardiac tissue to block sodium and calcium channels and in part to an antiischaemic effect associated with bradycardia and vasodepression."
3.	Hypoxia (Hypoxemia) 10/01/1995 - "There was no significant difference in potency between siratiazem and diltiazem in the presence of normal physiological salt solution (IC25 for siratiazem 0.13 +/- 0.04 microM and for diltiazem 0.08 +/- 0.02 microM) or one mimicking some of the conditions that occur during myocardial ischaemia (hypoxia, acidosis, reduced glucose and addition of lactate). "
4.	Acidosis 10/01/1995 - "There was no significant difference in potency between siratiazem and diltiazem in the presence of normal physiological salt solution (IC25 for siratiazem 0.13 +/- 0.04 microM and for diltiazem 0.08 +/- 0.02 microM) or one mimicking some of the conditions that occur during myocardial ischaemia (hypoxia, acidosis, reduced glucose and addition of lactate). "

Related Drugs and Biologics

1.	Diltiazem (Cardizem)
2.	Lactic Acid (Lactate)
3.	Calcium Channels (Calcium Channel)
4.	Solutions
5.	Sodium
6.	Salts
7.	Glucose (Dextrose)