cristacarpin

isolated from Erythrina burana; RN given refers to (6aS-cis)-isomer; structure given in first source

Also Known As:

(6aS,11aS)-9-methoxy-10-(3-methyl-2-buten-1-yl)-6H-benzofuro(3,2-c)(1)benzopyran-3,6a(11aH)-diol; Erythrabissin I; Erythrabyssin I

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hwang, Su Jung: 1 article (01/2022)
2.	Lee, Ho-Young: 1 article (01/2022)
3.	Lee, Hyo-Jong: 1 article (01/2022)
4.	Oh, Won Keun: 1 article (01/2022)
5.	Ali, Asif: 1 article (06/2016)
6.	Amin, Hina: 1 article (06/2016)
7.	Chakraborty, Souneek: 1 article (06/2016)
8.	Goswami, Anindya: 1 article (06/2016)
9.	Katoch, Archana: 1 article (06/2016)
10.	Kumar, Sunil: 1 article (06/2016)

Related Diseases

1.	Uveitis 01/01/2022 - "Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-κB." 01/01/2022 - "In the present study, the anti-inflammatory effect of cristacarpin on lipopolysaccharide (LPS)-induced inflammation was investigated using zebrafish embryos, RAW 264.7 macrophages, and mouse uveitis models. " 01/01/2022 - "In the non-toxic concentration range (from 20 to 100 μM), cristacarpin suppressed pro-inflammatory mediators such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, while stimulating anti-inflammatory mediators such as IL-4 and IL-10 in LPS-stimulated RAW 264.7 cells and uveitis mouse models. "
2.	Inflammation (Inflammations) 01/01/2022 - "In the present study, the anti-inflammatory effect of cristacarpin on lipopolysaccharide (LPS)-induced inflammation was investigated using zebrafish embryos, RAW 264.7 macrophages, and mouse uveitis models. "
3.	Neoplasms (Cancer) 01/01/2022 - "Cristacarpin is a novel prenylated pterocarpan that reportedly exhibits broad anti-cancer activity by enhancing endoplasmic reticulum stress. " 06/01/2016 - "Moreover, cristacarpin treatment induced p38MAPK, indicating the ROS-dependent activation of the MAP kinase pathway, and thus abrogates the tumor growth in mouse allograft tumor model. "
4.	Hepatocellular Carcinoma (Hepatoma) 12/05/2007 - "& Dalziel, six prenylated pterocarpans were isolated and analysed for pharmacological activity: While calopocarpin, cristacarpin, orientanol c, and isoneorautenol showed only a weak or moderate toxicity in H4IIE hepatoma cells (EC(50)-value> 25 microM), the toxicity of neorautenol and phaseollin was in the low micromolar range (EC(50)-value: 1 and 1.5 microM, respectively). "
5.	Breast Neoplasms (Breast Cancer) 06/01/2016 - "ultraviolet radiation (DNA damage), hydrogen peroxide (oxidative stress), chemotherapeutic agents (cytotoxic threat), etc. Here, we report that cristacarpin, a natural product obtained from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering senescence in pancreatic and breast cancer cells through blocking the cell cycle in the G1 phase. "

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Pterocarpans
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Interleukin-10 (Interleukin 10)
5.	Interleukin-4 (Interleukin 4)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Phosphotransferases (Kinase)
8.	Interleukins
9.	Hydrogen Peroxide (Hydroperoxide)
10.	neorautenol