transcription factor Brn-2

a CNS-specific POU transcription factor which is required for establishing mammalian neural cell lineages; amino acid sequence has been determined; RefSeq NM_005604 (human)

Also Known As:

BR-2 protein, human; BRN2 protein, human; Brain-2 protein, human; Brn-2 protein; Brn-2 transcription factor; N-Oct-3 protein; N-Oct-3 protein, human; OCT7 protein, human; POU domain, class 3, transcription factor 2 protein, human; POU3F2 protein, human; POUF3 protein, human; brain 2 protein, human

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - POU Domain Factors: 19
      - transcription factor Brn-2: 5
  - DNA-Binding Proteins: 2009
    - Homeodomain Proteins: 350
      - transcription factor Brn-2: 5
    - POU Domain Factors: 19
      - transcription factor Brn-2: 5

Experts

1.	Goding, Colin R: 3 articles (11/2012 - 04/2004)
2.	Dexter, Timothy J: 2 articles (04/2004 - 04/2004)
3.	Goodall, Jane: 2 articles (04/2004 - 04/2004)
4.	DiPersio, C Michael: 1 article (01/2021)
5.	Lamar, John M: 1 article (01/2021)
6.	Miskin, Rakshitha Pandulal: 1 article (01/2021)
7.	Ndoye, Abibatou: 1 article (01/2021)
8.	Warren, Janine S A: 1 article (01/2021)
9.	Wu, Lei: 1 article (01/2021)
10.	Bonvin, Elise: 1 article (11/2012)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 04/01/2004 - "The Brn-2 transcription factor links activated BRAF to melanoma proliferation." 04/01/2004 - "The POU domain transcription factor Brn-2 has been implicated in control of proliferation and melanoma survival, and its expression is strongly upregulated in melanoma. " 11/01/2012 - "In melanoma, the most aggressive and lethal form of skin cancer, the Brn-2 transcription factor (POU3F2) regulates proliferation and invasiveness and lies downstream from mitogen-activated protein kinase (MAPK) and Wnt/β-catenin, two melanoma-associated signaling pathways. " 02/01/1998 - "Reversible oxidation sensitivity of N-Oct-3 DNA binding activity was seen when melanoma extracts and recombinant Brn-2 protein were treated with a variety of metals, hydrogen peroxide and the cysteine disulphide bond forming agent diamide. "
2.	Skin Neoplasms (Skin Cancer) 11/01/2012 - "In melanoma, the most aggressive and lethal form of skin cancer, the Brn-2 transcription factor (POU3F2) regulates proliferation and invasiveness and lies downstream from mitogen-activated protein kinase (MAPK) and Wnt/β-catenin, two melanoma-associated signaling pathways. "
3.	Breast Neoplasms (Breast Cancer) 01/27/2021 - "Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor."

Related Drugs and Biologics

1.	Catenins
2.	Mitogen-Activated Protein Kinases
3.	Integrins
4.	Hydrogen Peroxide (Hydroperoxide)
5.	DNA (Deoxyribonucleic Acid)
6.	Diamide
7.	Cysteine (L-Cysteine)