adenophostin A

structure given in first source; an inositol-1,4,5-trisphosphate agonist isolated from Penicillium brevicompactum

Also Known As:

2'-Adenylic acid, 3'-O-(3,4-di-O-phosphono-alpha-D-glucopyranosyl)-

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Leukemia 11/27/1998 - "Effect of adenophostin A on Ca2+ entry and calcium release-activated calcium current (Icrac) in rat basophilic leukemia cells." 11/27/1998 - "In this study, we compared the abilities of adenophostin A and inositol 2,4,5-trisphosphate ((2, 4,5)IP3) to release Ca2+ from intracellular stores, to activate Ca2+ entry, and to activate calcium release-activated calcium current (Icrac) in rat basophilic leukemia cells. "
2.	Carcinoma (Carcinomatosis) 06/24/2014 - "For this demonstration, we encapsulated either inositol trisphosphate (IP3), an endogenous cell signaling second messenger, or adenophostin A (AdA), a potent analogue of IP, within 100 nm gold-coated liposomes, and injected these gold-coated liposomes and their contents into the cytosol of single ovarian carcinoma cells to initiate calcium (Ca(2+)) release from intracellular stores. "