afovirsen sodium

a phosphorothioate oligodeoxynucleotide; 20 nucleotides in length; base sequence given in first source

Also Known As:

IP-2105; ISIS 2105; ISIS-2105; Thymidine, 2'-deoxy-P-thiocytidylyl-(5'-3')-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thioguanylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-2'-deoxy-P-thiocytidy

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Condylomata Acuminata (Genital Wart) 12/01/1994 - "A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts." 10/01/1995 - "ISIS 2105 (Afovirsen), a 20-mer phosphorothioate oligonucleotide that inhibits the production of a gene product essential to the growth of human papillomavirus, is in phase II clinical trials for the treatment of genital warts induced by human papillomavirus-6 and human papillomavirus-11. " 04/01/1993 - "The first therapeutic oligonucleotide, ISIS 2105, an oligonucleotide designed to treat genital warts, has completed Phase I clinical trials and is undergoing Phase II testing. " 12/01/1993 - "5'-TTGCTTCCATCTTCCTCGTC-3' (ISIS 2105) is a phosphorothioate oligodeoxynucleotide currently being evaluated as an intralesional antiviral drug for the treatment of genital warts that are caused by the human papillomavirus. " 02/01/1993 - "These observations support the rationale of E2 as a target for antiviral therapy against papillomavirus infections and specifically identify ISIS 2105 as a candidate antisense oligonucleotide for the treatment of genital warts induced by HPV-6 and HPV-11."
2.	Papillomavirus Infections 02/01/1993 - "These observations support the rationale of E2 as a target for antiviral therapy against papillomavirus infections and specifically identify ISIS 2105 as a candidate antisense oligonucleotide for the treatment of genital warts induced by HPV-6 and HPV-11."

Related Drugs and Biologics

1.	Oligonucleotides
2.	Antiviral Agents (Antivirals)
3.	Antisense Oligonucleotides
4.	Oligodeoxyribonucleotides

Related Therapies and Procedures

1.	Therapeutics