etonitazene

was heading 1979-94 (see under BENZIMIDAZOLES 1979-90); ETONITAZIN was see ETONITAZENE 1979-94; use BENZIMIDAZOLES to search ETONITAZENE 1979-94; narcotic analgesic similar to morphine in action; used mainly to study narcotic habituation, tolerance, and withdrawal in laboratory animals

Also Known As:

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Aldy, Kim: 1 article (01/2022)
2.	Brent, Jeffrey: 1 article (01/2022)
3.	Calello, Diane P: 1 article (01/2022)
4.	Jefri, Mohamed: 1 article (01/2022)
5.	Krotulski, Alex: 1 article (01/2022)
6.	Logan, Barry: 1 article (01/2022)
7.	Manini, Alex F: 1 article (01/2022)
8.	Nguyen, Tuyet-Anh T: 1 article (01/2022)
9.	ToxIC Fentalog Study Group: 1 article (01/2022)
10.	Walton, Sara: 1 article (01/2022)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 03/01/1975 - "1-(BETA-Kiethylaminoethyl)-2-(p-ethoxybenzyl)-5-nitrobenzimidazole (u, etonitazene) is a potent analgesic that has value in drug addiction studies. " 01/01/2012 - "Considering etonitazene's properties, it seems reasonable to expected that long-term exposure to other benzimidazole derivatives may result in drug abuse and development of drug dependence."
2.	Body Weight (Weight, Body) 04/01/1986 - "Liquid intake and body weights were recorded every 24 hr. Etonitazene intake was compared to baseline water intake, and drug intake was then compared when the rats were food deprived (25 sessions) and food satiated (24 sessions). " 01/01/1981 - "During food deprivation etonitazene intake gradually increased to over two-fold as body weights decreased over 25 sessions; etonitazene intake was inversely proportional to body weight. " 12/08/1978 - "As the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (microgram/kg body weight) increased. " 01/01/1981 - "Changes in oral etonitazene self-administration were compared in four groups of rats that were maintained at 100, 95, 85, or 75% of their pre-experimental free-feeding body weights. "
3.	Self Mutilation 01/01/1981 - "The 75% weight group showed stereotypy, self-mutilation and large variability in daily etonitazene intake. " 01/01/1979 - "Self-mutilation and other forms of stereotypy were noted only in food-deprived rats consuming etonitazene."
4.	Polydipsia 08/01/1976 - "A pattern of schedule-induced polydipsia was maintained in rats by a fixed-time schedule where food pellets were presented every 90 sec, a fixed-interval schedule where licking the drinking tube produced pellets every 90 sec, or a fixed-interval schedule where lever presses produced pellets every 90 sec. Under all 3 schedules, injections of morphine, methadone, etonitazene and meperidine generally decreased licking rates and amounts of water consumed, as well as rates of lever-pressing under the schedules where lever presses were required. "
5.	Weight Loss (Weight Reduction) 02/01/1976 - "When naloxone (1.0 mg/kg) was administered after 12 days of drinking the drug solutions, the severity of the abstinence syndromes based on scoring of symptoms and on weight loss was morphine greater than or equal to etonitazine greater than levorphanol greater than meperidine greater than methadone. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Morphine (MS Contin)
3.	Methadone (Dolophine)
4.	Meperidine (Pethidine)
5.	Levorphanol (Levo-Dromoran)
6.	Fentanyl (Sublimaze)
7.	Astemizole
8.	Nocodazole
9.	Tinidazole
10.	Thiabendazole (Mintezol)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Injections
3.	Analgesia