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Ebola virus nucleoprotein VP35

a major nonphosphorylated nucleoprotein; 351 amino acid residues; amino acid sequence (second gene) given in first source

Also Known As:

nucleoprotein VP35, Ebola virus; Ebola virus VP35

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Viral Proteins: 4250
    - Viral Structural Proteins: 171
      - Nucleocapsid Proteins: 749
        Ebola virus nucleoprotein VP35: 4

Experts

1.	Basler, Christopher F: 2 articles (07/2013 - 07/2003)
2.	Amarasinghe, Gaya K: 1 article (07/2013)
3.	Ebihara, Hideki: 1 article (07/2013)
4.	Geisbert, Thomas W: 1 article (07/2013)
5.	Leung, Daisy W: 1 article (07/2013)
6.	Liu, Gai: 1 article (07/2013)
7.	Luthra, Priya: 1 article (07/2013)
8.	Mire, Chad E: 1 article (07/2013)
9.	Ramanan, Parameshwaran: 1 article (07/2013)
10.	Tsuda, Yoshimi: 1 article (07/2013)

Related Diseases

1.	Human Influenza (Influenza) 10/24/2000 - "When plasmids expressing individual Ebola virus proteins were transfected into Madin Darby canine kidney cells, the Ebola virus VP35 protein enhanced influenza delNS1 virus growth more than 100-fold. " 07/01/2003 - "The Ebola virus VP35 protein was previously found to act as an interferon (IFN) antagonist which could complement growth of influenza delNS1 virus, a mutant influenza virus lacking the influenza virus IFN antagonist protein, NS1. "
2.	Necrosis 02/01/2010 - "When expressed in mouse immature DCs, Ebola virus VP35 prevents virus-stimulated expression of CD40, CD80, CD86 and major histocompatibility complex class II. Further, it suppresses the induction of cytokines such as interleukin (IL)-6, IL-12, tumour necrosis factor alpha and alpha/beta interferon (IFN-alpha/beta). "
3.	Infections 07/17/2013 - "Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Interleukin-12 (IL 12)
3.	Interferon-beta
4.	Cytokines
5.	Interleukins
6.	Interferons
7.	Complement System Proteins (Complement)