propoxyphene napsylate

was heading 1976-94 (see under PROPOXYPHENE 1976-90); use PROPOXYPHENE to search PROPOXYPHENE NAPSYLATE 1976-94; less potent, but less irritating analog of propoxyphene; used as analgesic; the dextro isomer has little antitussive action but the levo is mainly used as an antitussive effects toxicity as

Also Known As:

d-propoxyphene napsylate; dextropropoxyphene napsylate; 2-Naphthalenesulfonic acid, compd. with (S-(R*,S*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)p- ropyl propanoate (1:1)

Networked: 28 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Propionates: 988
      - Dextropropoxyphene: 382
        propoxyphene napsylate: 28

Related Diseases

1.	Pain (Aches) 03/01/1993 - "Any patient who required medication stronger than Darvocet-N-100 (propoxyphene napsylate and acetaminophen; Eli Lilly and Co., Indianapolis, IN) for pain was considered a failure. " 01/01/1979 - "One investigator at each of 4 institutions followed the requirements of a core protocol designed to evaluate propoxyphene napsylate (50, 100 and 150 mg), fenoprofen calcium (200, 400 and 600 mg) and their combination (50/200, 100/400 and 150/600 mg) in patients reporting postpartum pain. " 01/01/1972 - "[Analgesic effects of d-propoxyphene napsylate for the pain following tooth extraction--comparison of Sedes and placebo in the double blind study]." 06/20/1977 - "In a double-blind control study, oral doses of placebo, propoxyphene napsylate (50 or 100 mg), or codeine sulfate (30 or 60 mg) were administered to 46 postepisiotomy patients, grouped by severity of pain reported at first-dose drug administration. " 11/01/1989 - "A comparison of the efficacy and tolerability of diflunisal and dextropropoxyphene napsylate with acetaminophen in the management of mild to moderate pain after arthroscopy of the knee."
2.	Postoperative Pain 04/01/1972 - "[Effect of d-propoxyphene napsylate (S-9700) on postoperative pain]." 01/01/1985 - "Comparison of diflunisal and dextropropoxyphene napsylate in the treatment of post-operative pain." 02/01/1987 - "To determine the effect of pretreatment and multiple doses on postsurgical pain, a study of the relative analgesic efficacy of placebo, acetaminophen 650 mg, and propoxyphene napsylate 100 mg alone and in combination was conducted. " 01/01/1985 - "A double-blind study of 43 patients undergoing excision of haemorrhoids under spinal anaesthesia was carried out to compare the analgesic effects of diflunisal (DFL, 21 patients) and dextropropoxyphene napsylate (DPN, 22 patients) on post-operative pain. " 06/01/1992 - "The purpose of this single-dose, double-blind, placebo-controlled study was to determine the analgesic effectiveness of an oral administration of two dose levels of tramadol hydrochloride (75 or 150 mg) compared with the combination of 650 mg acetaminophen plus 100 mg propoxyphene napsylate in 161 patients with severe postoperative pain after cesarean section. "
3.	Heroin Dependence (Heroin Abuse) 09/01/1981 - "A man who was prescribed propoxyphene napsylate (PN) for treatment of heroin addiction stated that he received no effect from the drug by the oral route. " 11/19/1973 - "Letter: Propoxyphene napsylate for heroin addiction." 01/01/1974 - ""I got a yen for that darvon-N": a pilot study on the use of propoxyphene napsylate in the treatment of heroin addiction." 07/01/1977 - "Notes on Alcoholism and Drug Abuse: Propoxyphene-Napsylate (Darvon-N or PN) in the Treatment of Heroin Dependence."
4.	Narcotic-Related Disorders 01/01/1979 - "Usefulness of propoxyphene napsylate for maintenance treatment of narcotic addiction." 08/01/1983 - "In four children with iatrogenic morphine sulfate tolerance and dependence, narcotic withdrawal was successfully accomplished using propoxyphene napsylate. " 04/01/1982 - "Propoxyphene napsylate maintenance treatment of narcotic dependence: use of a non-methadone model." 08/01/1981 - "Propoxyphene napsylate maintenance treatment for narcotic dependence: a non-methadone model."
5.	Opioid-Related Disorders (Opiate Addiction) 04/01/1982 - "Clinical comparison of propoxyphene napsylate and methadone in the treatment of opiate dependence." 01/01/1981 - "Propoxyphene napsylate compared to methadone for opiate dependence."

Related Drugs and Biologics

1.	Acetaminophen (Paracetamol)
2.	Analgesics (Analgesic Drugs)
3.	Tramadol (K315)
4.	Codeine (Codeine Phosphate)
5.	solpadeine
6.	Sulfates (Sulfates, Inorganic)
7.	Caffeine (No Doz)
8.	Methadone (Dolophine)
9.	Dextropropoxyphene (Darvon)
10.	Naproxen (Naprosyn)

Related Therapies and Procedures

1.	Cesarean Section (Caesarean Section)
2.	Tonsillectomy
3.	Oral Administration
4.	Tooth Extraction (Tooth Extractions)
5.	Meniscectomy