DV 7751a

a fluoroquinolone with an aminopyrrolidine substituent at the C-10 position of the benzoxazine skeleton; structure given in first source

Also Known As:

DV 7751; DV-7751; DV-7751a; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 10-(8-amino-6-azaspiro(3.4)oct-6-yl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S-(R*,R*))-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        Fluoroquinolones: 5348
        DV 7751a: 3

Related Diseases

1.	Phototoxic Dermatitis (Phototoxicity) 06/01/1996 - "DV-7751a showed very weak phototoxicity in mice after single oral administration of 600 mg/kg, followed by UVA irradiation, but no convulsion after oral administration of 200 or 1000 mg/kg in combination with 4-biphenylacetic acid at 400 mg/kg."
2.	Vomiting 06/01/1996 - "A single oral administration of DV-7751a induced soft stool in rats at 1000 and 2000 mg/ kg and in monkeys at 250 mg/kg and vomiting in monkeys at 500 mg/kg or more. "
3.	Joint Diseases (Joint Disease) 09/01/1997 - "In immature dogs (n = 3) orally given DV-7751a at 5, 10 and 15 mg/kg for 8 days, arthropathy in the femur of a dog receiving 15 mg/kg was observed at termination, but not at the lower doses. "
4.	Infections 07/01/1995 - "DV-7751a appears to be a candidate for the therapy of some mixed-flora infections and the treatment of bacteria resistant to the current fluoroquinolones."
5.	Diarrhea 09/01/1997 - "In mature monkeys (n = 3) treated orally with DV-7751a at 100 mg/kg for 14 days, no toxic effects were found except for mild diarrhea throughout the experiment. "

Related Drugs and Biologics

1.	Fluoroquinolones
2.	Acids

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration