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vescalagin

structure in first source; castalagin is the (33beta)-isomer of vescalagin

Also Known As:

castalagin; vescalagin, (33beta)-isomer; vescalene; vescalin

Networked: 15 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chang, Wen-Chang: 5 articles (07/2021 - 01/2013)
2.	Shen, Szu-Chuan: 5 articles (07/2021 - 01/2013)
3.	Wu, James Swi-Bea: 3 articles (07/2021 - 07/2013)
4.	Dakhli, Thierry: 1 article (11/2018)
5.	Deffieux, Denis: 1 article (11/2018)
6.	Delannoy López, Daniela Melanie: 1 article (11/2018)
7.	Fremaux, Isabelle: 1 article (11/2018)
8.	Georgess, Dan: 1 article (11/2018)
9.	Génot, Elisabeth: 1 article (11/2018)
10.	Jurdic, Pierre: 1 article (11/2018)

Related Diseases

1.	Insulin Resistance 02/01/2013 - "We postulate that vescalagin is an active component in PWFE that may alleviate the insulin resistance in mouse hepatocytes." 02/10/2016 - "Vescalagin from Pink Wax Apple [Syzygium samarangense (Blume) Merrill and Perry] Alleviates Hepatic Insulin Resistance and Ameliorates Glycemic Metabolism Abnormality in Rats Fed a High-Fructose Diet." 02/10/2016 - "This study investigates the ameliorative effect of vescalagin (VES) isolated from Pink wax apple fruit on hepatic insulin resistance and abnormal carbohydrate metabolism in high-fructose diet (HFD)-induced hyperglycemic rats. " 07/24/2013 - "Vescalagin (VES) is an ellagitannin that alleviates insulin resistance in cell study. "
2.	Inflammation (Inflammations) 07/15/2021 - "Vescalagin from Pink Wax Apple (Syzygium samarangense (Blume) Merrill and Perry) Protects Pancreatic β-Cells against Methylglyoxal-Induced Inflammation in Rats." 07/24/2013 - "Protective effects of vescalagin from pink wax apple [Syzygium samarangense (Blume) Merrill and Perry] fruit against methylglyoxal-induced inflammation and carbohydrate metabolic disorder in rats."
3.	Infections 11/01/2023 - "We study castalagin's activity towards HSV-1 infection in newborn mice. " 11/01/2023 - "Effect of castalagin against HSV-1 infection in newborn mice."
4.	Neoplasms (Cancer) 01/01/2023 - "Work in murine models demonstrated that castalagin, the active compound in CC, preferentially binds to beneficial gut microbiome bacteria, promoting a stronger CD8+T cell anti-cancer response. " 08/01/1992 - "Among them, chebulagic acid [1], geraniin [2], sanguiin H-11 [3], 4,5-di-O-galloylquinic acid [12], 1,3,4,5-tetra-O-galloylquinic acid [15], 1(beta)-O-galloylpedunculagin [24], furosin [29], castalagin [38], sanguiin H-2 [34], vescalagin [39], grandinin [40], phyllyraeoidin A [42], (-)-epicatechin 3-O-gallate [50], cinnamtannin B2 [55], and acutissimin A [56] exhibited moderate selective cytotoxicity against PRMI-7951 melanoma cells with ED50 values in the range of 0.1-0.8 microgram/ml. Selective cytotoxicities against the melanoma cells were also observed for strictinin [22], pedunculagin [23], eugeniin [25], elaeocarpusin [28], punicacortein C [37], casuarinin [41], sanguiin H-6 [43], procyanidin B-2 3,3'-di-O-gallate [51], procyanidin C-1 3,3',3"-tri-O-gallate [52], and cinnamtannin B1 [54] with ED50 values of 1-4 micrograms/ml. All of the tannins were found to be inactive (greater than 10 micrograms/ml) against lung carcinoma (A-549), ileocecal adenocarcinoma (HCT-8), epidermoid carcinoma of nasopharnyx (KB), and medulloblastoma (TE-671) tumor cells."
5.	Carcinoma (Carcinomatosis) 05/14/2008 - "The ellagitannins castalagin and vescalagin, and the C-glycosides grandinin and roburin E as well as ellagic acid were found to potently inhibit the growth of human colon carcinoma cells (HT29) in vitro. " 08/01/1992 - "Among them, chebulagic acid [1], geraniin [2], sanguiin H-11 [3], 4,5-di-O-galloylquinic acid [12], 1,3,4,5-tetra-O-galloylquinic acid [15], 1(beta)-O-galloylpedunculagin [24], furosin [29], castalagin [38], sanguiin H-2 [34], vescalagin [39], grandinin [40], phyllyraeoidin A [42], (-)-epicatechin 3-O-gallate [50], cinnamtannin B2 [55], and acutissimin A [56] exhibited moderate selective cytotoxicity against PRMI-7951 melanoma cells with ED50 values in the range of 0.1-0.8 microgram/ml. Selective cytotoxicities against the melanoma cells were also observed for strictinin [22], pedunculagin [23], eugeniin [25], elaeocarpusin [28], punicacortein C [37], casuarinin [41], sanguiin H-6 [43], procyanidin B-2 3,3'-di-O-gallate [51], procyanidin C-1 3,3',3"-tri-O-gallate [52], and cinnamtannin B1 [54] with ED50 values of 1-4 micrograms/ml. All of the tannins were found to be inactive (greater than 10 micrograms/ml) against lung carcinoma (A-549), ileocecal adenocarcinoma (HCT-8), epidermoid carcinoma of nasopharnyx (KB), and medulloblastoma (TE-671) tumor cells."

Related Drugs and Biologics

1.	Fructose
2.	Pyruvaldehyde (Methylglyoxal)
3.	Carbohydrates
4.	ellagitannin
5.	vescalagin
6.	Hydrolyzable Tannins
7.	Tannins
8.	Proteins (Proteins, Gene)
9.	Acids
10.	grandinin