3-hydroxy-5-estrane-17-carbonitrile (ACN)

12/01/2006 - "This study looked at ascertaining the efficacy of Advanced Clinical Nurses' (ACN) suturing dermal lacerations in tertiary, regional and rural ED settings. "
12/01/2006 - "Eighty patients requiring sutures for dermal lacerations that were repaired by an ACN. "

01/01/2012 - "To evaluate the long-term efficacy of arytenoid adduction (AA) combined with ansa cervicalis-recurrent laryngeal nerve anastomosis (ACN-RLN) in the treatment of unilateral vocal fold paralysis. "

07/01/2015 - "Sixth Annual General Meeting Anzup Cancer Trials Group Ltd (Anzup) (ACN 133 634 956)."
08/01/2007 - "The aim of this study is to screen a series of ACN for the presence of a number of viruses known to play a role in cancer. "
12/01/1997 - "Our evaluation of the more recent human database taken as a whole shows that there is not a clear association between ACN exposure and human cancer, yet the studies have insufficient power to be able to rule out a small increase. "
10/08/2015 - "Systemic administration of two different P2X7 antagonists (AZ10606120 or A740003) in nude/nude mice reduced ACN-derived tumor growth. "
10/01/2014 - "Expression of HLA-II in ESCC was significantly higher than that in cancer adjacent normal (ACN) samples (P < 0.05). "

10/01/2010 - "This present study investigated whether ACN induces apoptosis in human neuroblastoma SH-SY5Y cells, and whether its apoptotic induction involves oxidative stress. "
11/01/2006 - "Therefore, this study examined whether ACN altered the activation state of ERK1/2 in human neuroblastoma SK-N-SH cells. "
08/24/2004 - "In this study, in an attempt to identify neuroblastoma-associated surface antigens, we generated mAbs against the ACN neuroblastoma cell line. "
01/01/2012 - "In the human neuroblastoma cell line ACN, lactate output is also dependent on P2X7R function. "
10/30/2003 - "No induction of surface or intracellular HLA class II molecules and of specific mRNA was observed, in all neuroblastomas, with the exception of a nonprototypic cell line, ACN. "

10/01/1993 - "This discordance between laboratory animal and human study findings is explored by determining post hoc the statistical power of 11 epidemiologic studies of ACN-exposed workers to detect the all-site and brain cancer excesses that are projected from rodent drinking water bioassay data. "
04/01/2000 - "Previous studies demonstrated that ACN induces brain neoplasms (predominately astrocytomas) in rats following chronic treatment. "
11/01/1982 - "To study the possibility that liver metabolism of acrylonitrile (ACN) could produce a stable carcinogenic metabolite that causes the brain tumors produced by ACN, the ability of hepatocytes to generate a stable transportable mutagenic metabolite in culture was studied. "
06/01/1998 - "To examine the possibility that ACN-related brain tumors were not a consequence of binding of ACN to brain DNA, experiments were conducted to investigate possible epigenetic mechanisms. "
06/01/1998 - "No adducts have been detected in brain DNA from ACN-exposed rats, suggesting that brain tumors may have arisen by mechanisms other than ACN-DNA reactivity. "