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neurotensin mimic 2 (mimic 2)
a neurotensin mimetic; structure given in first source
Also Known As:
mimic 2
; NT mimic 2
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
neurotensin mimic 2: 2
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
neurotensin mimic 2: 2
Experts
1.
Inoue, Masayuki
: 1 article (01/2013)
2.
Itoh, Hiroaki
: 1 article (01/2013)
Related Diseases
1.
Leukemia
01/10/2013 - "
We recently designed and synthesized a simplified dansylated polytheonamide mimic 2, in which six amino acid residues were modified from 1, and demonstrated that 2 emulated the functions of 1. Here we report a comprehensive structure-activity relationship study of substructures of 2. A unified synthetic strategy was developed for highly automated syntheses of 13 peptide sequences of 27 to 39 amino acid residues, and the artificial 37-mer peptide 6 was discovered to be significantly more toxic than the other 12 compounds toward P388 mouse leukemia cells (IC50 = 3.7 nM).
"
2.
Contact Dermatitis (Eczema, Contact)
10/01/1991 - "
Tumor necrosis factor alpha (TNF alpha) has been shown to mimic 2 effects of ultraviolet B (UVB) radiation in mice: morphologic damage to epidermal Langerhans cells (LC) and the inability to mount a normal contact hypersensitivity (CH) response.
"
Related Drugs and Biologics
1.
Peptides (Polypeptides)
2.
Amino Acids
3.
Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)