clemizole

11/01/2014 - "Clemizole was not only effective in blocking heterologously expressed TRPC5 homomers but also TRPC1:TRPC5 heteromers as well as native TRPC5-like currents in the U-87 glioblastoma cell line. "
01/01/2021 - "Finally, we identified five potential therapeutic drugs (bacitracin, hecogenin, clemizole, chrysin, and gibberellic acid) that may be effective treatments for glioblastoma."

01/01/2013 - "Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment."
01/01/2022 - "Clemizole and trazodone were previously identified in a larval zebrafish model for Dravet syndrome. "
01/01/2017 - "Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome."
12/01/2023 - "Drug-repurposing approaches for SCN1A-related Dravet syndrome are currently under investigation (i.e., lorcaserin, clemizole, and ataluren). "
01/01/2019 - "To investigate the serotonin receptors that could moderate this antiepileptic activity, we designed and synthesized 28 novel analogues of clemizole, obtained receptor binding affinity profiles, and performed in vivo screening in a scn1lab mutant zebrafish (Danio rerio) model which recapitulates critical clinical features of Dravet syndrome. "

03/03/1969 - "[Treatment of circular movement auricular flutter (the use of an antihistaminic: clemizole)]."
01/01/1969 - "Antiarrhythmic actions of clemizole as pharmacologic evidence for a circus movement mechanism in atrial flutter."
05/01/1967 - "[The antihistaminic clemizole in auricular flutter caused by circular movement]."

01/01/2013 - "A phenotype-based screen of 320 compounds identifies a US Food and Drug Administration-approved compound (clemizole) that inhibits convulsive behaviours and electrographic seizures. "
01/01/2017 - "Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome."

02/01/2013 - "Therefore, we investigated whether they could provide a more predictive assessment for clemizole, a drug in clinical development for the treatment of hepatitis C virus (HCV) infection. "
01/01/2017 - "Thus, caution should be taken when clemizole is used as a TRPC5 channel blocker or for treating hepatitis C infection."
01/01/2017 - "Clemizole, a histamine H1 receptor antagonist has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. "