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valacyclovir (valaciclovir)

Subscribe to New Research on valacyclovir

a prodrug of acyclovir; 53% of oral dose excreted as acyclovir in the urine; a 200-400% improvement on acyclovir; used in the management of HSV and VZV infections and the prophylaxis of HCMV infections; RN given refers to the monohydrochloride L-valine isomer

Also Known As:

valaciclovir; Valtrex; 256U87; 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl L-valinate; 256U; BW256U87; L-valylacyclovir; acyclovir, L-valyl ester; valacyclovir hydrochloride; valacyclovir hydrochloride, (DL)-isomer; valacyclovir, (D)-isomer; valacyclovir, (DL)-isomer; valacyclovir, (L)-isomer; valacyclovir, x-hydrochloride, (D)-isomer; valacyclovir, x-hydrochloride, (DL)-isomer

Networked: 492 relevant articles (98 outcomes, 106 trials/studies)

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Drug Context: Research Results

Experts

1.	Wald, Anna: 11 articles (01/2013 - 10/2003)
2.	Tyring, Stephen: 9 articles (04/2012 - 09/2006)
3.	Tyring, Stephen K: 8 articles (08/2012 - 10/2002)
4.	Warren, Terri: 7 articles (04/2008 - 10/2003)
5.	Corey, Lawrence: 5 articles (02/2012 - 01/2004)
6.	Fife, Kenneth H: 5 articles (01/2009 - 10/2006)
7.	Suzuki, Hiroshi: 4 articles (04/2013 - 08/2010)
8.	Mendoza, Natalia: 4 articles (08/2011 - 05/2008)
9.	Brennan, Clare A: 4 articles (01/2009 - 10/2003)
10.	Legendre, Christophe: 4 articles (05/2006 - 10/2002)

Related Diseases

1.	Infection 04/01/1997 - "This study has demonstrated that once daily valaciclovir (500 mg), is highly effective and well tolerated for the suppression of recurrent genital HSV infection. " 01/01/2009 - "Our study is the first to demonstrate a significant reduction in viral shedding with valacyclovir 1 g daily compared to placebo in a population of subjects newly diagnosed with HSV-2 infection." 07/01/2009 - "It is concluded, that continuous suppressive therapy of HSV infections with valacyclovir is safe and effective treatment, which strongly prevents reoccurrence or transmissions of HSV infections to sexual partners. " 08/01/2002 - "We concluded that the 16 CFS patients (included in both phases of this study) with EBV-persistent infection (EBV single-virus subset) are improved after 6 months of continuous pharmacokinetic dosing with valacyclovir. " 08/01/2002 - "This study was designed to determine safety and efficacy of a 6-month trial of valacyclovir in single-virus Epstein-Barr virus (EBV) persistent infection. "
2.	Herpes Genitalis (Genital Herpes) 07/01/1999 - "Valacyclovir HCl was highly effective and well tolerated as continuous suppressive therapy in men and women with recurrent genital herpes. " 09/01/1998 - "Thus, valaciclovir is highly effective and well tolerated for suppression of recurrent genital herpes. " 11/01/2004 - "Valacyclovir at 500 mg twice daily was effective in preventing or delaying recurrences of genital herpes compared with placebo (hazard ratio, 0.20; 95% CI, 0.13-0.30; P<.001) and with valacyclovir at 1000 mg once daily (hazard ratio, 0.56; 95% CI, 0.40-0.80; P=.001), in 6-month and 48-week studies, respectively. " 10/01/1999 - "A double-blind, randomized, controlled, multicriteria equivalence trial was conducted to determine whether od treatment with valacyclovir 1000 mg is as effective as bd treatment with 500 mg in patients with recurrent genital herpes. " 07/01/2008 - "Valacyclovir 1 g once daily administered for 24 weeks was well-tolerated and effective in suppressing genital herpes recurrences in immunocompetent newly diagnosed persons without an established recurrence pattern."
3.	Herpes Zoster 01/01/2014 - "[Ophthalmic zoster of th eyelid: good outcome with valaciclovir]." 09/01/2000 - "Current wholesale prices indicate that valacyclovir is the more cost-effective treatment for herpes zoster ($83.90 vs $140.70 per course)." 05/01/2007 - "Oral valacyclovir 1.5 g bid is safe and effective for the treatment of uncomplicated herpes zoster in immunocompetent patients over 18 years of age. " 05/01/2008 - "The objective of this study was to assess the safety and efficacy of an oral dosage of valacyclovir, 1 g TID versus 2 g TID, for the treatment of herpes zoster in immunocompromised patients > or =18 years of age. " 05/01/2007 - "To demonstrate the safety and efficacy of oral valacyclovir 1.5 g twice daily (bid) for the treatment of uncomplicated herpes zoster in immunocompetent patients over 18 years of age. "
4.	Pain (Aches) 08/01/2012 - "No EPB-348 group was non-inferior to valacyclovir for time to cessation of new lesion formation or time to cessation of pain by Day 120, though no significant differences occurred between treatment groups. " 09/01/2004 - "The mean time to pain cessation was significantly less in the valacyclovir group (3.2 days) than in the placebo group (6.2 days) (P = .006). " 04/01/2004 - "The effect of valacyclovir on pain and tenderness and FIQ did not differ from placebo. " 03/01/2003 - "The time to lesion healing and time to cessation of pain and/or discomfort were statistically significantly reduced with valacyclovir compared to placebo. " 08/12/1996 - "Valaciclovir therapy provided a clinically significant benefit to patients that included shortening of the duration of lesions, the duration of pain or discomfort, and the duration of virus shedding. "
5.	Postherpetic Neuralgia 07/01/1995 - "Treatment with valaciclovir also significantly reduced the duration of postherpetic neuralgia and decreased the proportion of patients with pain persisting for 6 months (19.3 versus 25.7%). " 07/01/2006 - "Improvement of postherpetic neuralgia after treatment with intravenous acyclovir followed by oral valacyclovir." 08/01/2011 - "To evaluate the efficacy of treatment with gabapentin plus valacyclovir hydrochloride for the prevention of postherpetic neuralgia in patients with acute herpes zoster. " 08/01/2011 - "Incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster: open-label study." 08/01/2011 - "Prevent rather than treat postherpetic neuralgia by prescribing gabapentin earlier in patients with herpes zoster: comment on "incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster"."

Related Drugs and Biologics

1.	Acyclovir (Aciclovir)
2.	famciclovir (Famvir)
3.	Ganciclovir (Cytovene)
4.	Antiviral Agents (Antivirals)
5.	valacyclovir (valaciclovir)
6.	cidofovir (Vistide)
7.	penciclovir (Denavir)
8.	brivudine (brivudin)
9.	Prednisone (Sone)
10.	Foscarnet

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Transplants (Transplant)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Stem Cell Transplantation
5.	Intravitreal Injections