cathelin

amino acid sequence given in first source; an 11-kDa protein isolated from porcine leukocytes; a non-inhibitory protein similar to pro-regions of antibacterial peptides

Networked: 10 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yu, Haining: 2 articles (08/2012 - 05/2011)
2.	Zhu, Wenjuan: 2 articles (08/2012 - 05/2011)
3.	Clarke, Robert: 1 article (01/2021)
4.	Kubes, Paul: 1 article (01/2021)
5.	Mohapatra, Saswat: 1 article (01/2021)
6.	Mondal, Debajyoti: 1 article (01/2021)
7.	Ortega, Mireia: 1 article (01/2021)
8.	Santamaria, Pere: 1 article (01/2021)
9.	Serra, Pau: 1 article (01/2021)
10.	Singha, Santiswarup: 1 article (01/2021)

Related Diseases

1.	Infections 12/04/1995 - "These data suggest that the panoply of porcine cathelin-associated antimicrobial peptides arose relatively recently via gene reduplications and exon shuffling, and that in vivo expression of cathelin-associated antimicrobial peptides may respond to mediators generated early during infection." 08/01/2012 - "Cathelicidins comprise a family of antimicrobial peptides (AMPs) sharing a highly conserved cathelin domain, and play a central role in the innate defense against infection in most of vertebrates. " 05/01/2011 - "Cathelicidins comprise a family of antimicrobial peptides sharing a highly conserved cathelin domain, which play a central role in the early innate host defense against infection. " 11/01/2007 - "LBs encapsulate antimicrobial peptides (AMPs), and PS or systemic or topical GC administration downregulated epidermal expression of murine AMPs cathelin-related AMP and beta-defensin 3. Pharmacological blockade of the stress hormone corticotrophin-releasing factor or of peripheral GC action, as well as topical administration of physiologic lipids, normalized epidermal AMP levels and delivery to LBs and decreased the severity of GAS infection during PS. "
2.	Colitis 01/01/2019 - "This is the first report showing the protective effects of PG-1 in its various forms (pro-, cathelin-, and mature-forms) in attenuating significant body weight loss associated with DSS-induced colitis (p < 0.05). "
3.	Body Weight (Weight, Body) 01/01/2019 - "This is the first report showing the protective effects of PG-1 in its various forms (pro-, cathelin-, and mature-forms) in attenuating significant body weight loss associated with DSS-induced colitis (p < 0.05). "
4.	Muscle Cramp (Cramp) 03/01/2010 - "CRAMP, the unique antimicrobial peptide derived from cathelin in mouse inhibited all the responses coupled to P2X(7) receptors in macrophages from WT mice. " 02/01/2005 - "Both mig-14 and virK contribute to the survival of Salmonella in macrophages treated with IFN-gamma and are necessary for resistance to cathelin-related anti-microbial peptide (CRAMP), an anti-microbial peptide expressed at high levels in activated mouse macrophages. " 09/01/2010 - "The cathelin-related anti-microbial peptide (CRAMP) is the only cathelicidin isolated from mice. " 01/01/2021 - "The liver-associated neutrophils from the treated mice, unlike their circulating counterparts or the liver neutrophils of sick mice lacking antigen-specific TR1 cells, are proliferative, can transfer disease protection to immunocompromised hosts engrafted with pathogenic effectors, and blunt antigen-presentation and local autoimmune responses via cathelin-related anti-microbial peptide (CRAMP), a cathelicidin, in a CRAMP-receptor-dependent manner. "
5.	Inflammation (Inflammations) 08/01/2023 - "Cbf-14, a cationic peptide derived from cathelin-domain, exhibits anti-inflammation activity via inhibiting PI3K- Akt /ROS/ NF-κB signaling pathway."

Related Drugs and Biologics

1.	Antimicrobial Peptides
2.	beta-Defensins
3.	Lipids
4.	Hormones (Hormone)
5.	Adrenocorticotropic Hormone (ACTH)
6.	Adenosine Monophosphate (AMP)
7.	Cathelicidins
8.	Peptides (Polypeptides)
9.	Antigens

Related Therapies and Procedures

1.	Topical Administration