EXP 063

to search, use E#P063(nm); angiotensin II receptor antagonist; structure given in first source

Also Known As:

4-((4-((3-(N-isopropylamino)-2-hydroxypropyl)oxy)indole-2-carboxamido)methyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)imidazole-5-carboxylic acid; EXP-063; EXP063

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - EXP 063: 1
    - Tetrazoles: 14
      - EXP 063: 1

Related Diseases

1.	Hypertension (High Blood Pressure) 11/01/1993 - "In renal hypertensive rats, EXP063 given i.v. produced a long-lasting decrease in blood pressure for at least 6 hr with an ED30 of 0.53 mg/kg. In summary, this study demonstrates that EXP063 is a novel chemical entity possessing both the Ang II and beta adrenergic receptor blocking properties and, thus, represents a promising agent for the treatment of hypertension and congestive heart failure."
2.	Heart Failure 11/01/1993 - "In renal hypertensive rats, EXP063 given i.v. produced a long-lasting decrease in blood pressure for at least 6 hr with an ED30 of 0.53 mg/kg. In summary, this study demonstrates that EXP063 is a novel chemical entity possessing both the Ang II and beta adrenergic receptor blocking properties and, thus, represents a promising agent for the treatment of hypertension and congestive heart failure."

Related Drugs and Biologics

1.	beta Adrenergic Receptors