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4- tert- butyl- (3- (2- chloroethyl)ureido)benzene

structure given in first source

Also Known As:

tBCEU

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - 4-tert-butyl-(3-(2-chloroethyl)ureido)benzene: 4
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        4-tert-butyl-(3-(2-chloroethyl)ureido)benzene: 4

Experts

1.	Madelmont, Jean-Claude: 2 articles (11/2005 - 07/2004)
2.	Miot-Noirault, Elisabeth: 2 articles (11/2005 - 07/2004)
3.	Mounetou, Emmanuelle: 2 articles (11/2005 - 07/2004)
4.	Bouchon, Bernadette: 1 article (11/2005)
5.	Chambon, Christophe: 1 article (11/2005)
6.	Degoul, Françoise: 1 article (11/2005)
7.	Gaudreault, René C: 1 article (11/2005)
8.	Papon, Janine: 1 article (11/2005)
9.	C -Gaudreault, René: 1 article (07/2004)
10.	Côté, Marie-France: 1 article (07/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1994 - "This lack of cross-resistance in various resistant tumor cells suggests that tBCEU could be potentially useful in the treatment of cancers resistant to conventional anticancer drugs." 07/01/2004 - "Accordingly, tBCEU and ICEU also inhibited the migration and proliferation of endothelial and tumor cells in vitro in a dose-dependent manner. " 11/01/2005 - "tBCEU was supposed to bind covalently to cysteine 239 of beta-tubulin, but this binding site was not clearly confirmed (Cancer Res 60:985-992, 2000). "
2.	Breast Neoplasms (Breast Cancer) 09/01/1993 - "To optimize the pharmacological and the biological properties of this new class of compounds and to determine its mechanism of action, at the cellular level, we studied the effect of 4-tert-butyl-[3-(2-chloroethyl) ureido] benzene (tBCEU) on MDA-MB-231, a human breast cancer hormone-independent cell line. "

Related Drugs and Biologics

1.	Tubulin
2.	Hormones (Hormone)
3.	Cysteine (L-Cysteine)
4.	Benzene (Benzole)