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ribonuclease 4

amino acid sequence given in first source; cleaves specifically on the 3' side of uridine

Also Known As:

RNase4 protein, human; ribonuclease 4, human

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Ribonucleases: 2046
        ribonuclease 4: 9

Experts

1.	Sheng, Jinghao: 3 articles (01/2022 - 04/2013)
2.	Xu, Zhengping: 3 articles (01/2022 - 04/2013)
3.	Gomes, James: 3 articles (12/2019 - 01/2019)
4.	Padhi, Aditya K: 3 articles (12/2019 - 01/2019)
5.	Li, Shuping: 2 articles (01/2022 - 04/2013)
6.	Narain, Priyam: 2 articles (12/2019 - 01/2019)
7.	Hu, Guo-fu: 2 articles (05/2014 - 04/2013)
8.	Hu, Guo-Fu: 1 article (01/2022)
9.	Vanli, Nil: 1 article (01/2022)
10.	Bender, Kristin: 1 article (01/2021)

Related Diseases

1.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/01/2019 - "A molecular dynamics based investigation reveals the role of rare Ribonuclease 4 variants in amyotrophic lateral sclerosis susceptibility." 01/01/2019 - "Insights into the role of ribonuclease 4 polymorphisms in amyotrophic lateral sclerosis." 12/01/2019 - "Rare Angiogenin and Ribonuclease 4 variants associated with amyotrophic lateral sclerosis exhibit loss-of-function: a comprehensive in silico study."
2.	Urinary Tract Infections (Urinary Tract Infection) 01/01/2023 - "Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection." 01/01/2021 - "These data show that RNase 4 has antibacterial activity against UPEC, is expressed in the human urinary tract, and can contribute to host defense against urinary tract infections.NEW & NOTEWORTHY Ribonuclease 4 (RNase 4) is a newly identified host defense peptide in the human kidney and bladder. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 05/02/2014 - "Angiogenin (ANG) and ribonuclease 4 (RNASE4), two members of the secreted and vertebrate-specific ribonuclease superfamily, play important roles in cancers and neurodegenerative diseases. "
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2022 - "Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer."
5.	Nerve Degeneration 04/01/2013 - "Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress."

Related Drugs and Biologics

1.	angiogenin
2.	Ribonucleases (Ribonuclease)
3.	Histone Deacetylase Inhibitors
4.	Adrenomedullin
5.	Antimicrobial Cationic Peptides
6.	Pancreatic Ribonuclease (Ribonuclease A)
7.	Proteins (Proteins, Gene)
8.	Epidermal Growth Factor (EGF)
9.	Discoidins