T103N

alteplase variant; contains additional glycosylation site in the first kringle domain; causes substantial reduction in clearance rate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Protein S Deficiency (Deficiency, Protein S) 09/01/2000 - "A naturally occurring Thr103Asn (T103N) mutation in the first EGF-like domain of protein S has been associated with functional (type II) protein S deficiency. "
2.	Thrombosis (Thrombus) 08/02/1993 - "Potency of the variants relative to t-PA on whole blood clots ranged from 0.9 (T103N, KHRR 296-299 AAAA) to 1.7 (T103N). "