bulbocapnine

was heading 1975-94 (Prov 1975-90); use APORPHINES to search BULBOCAPNINE 1975-94 (as Prov 1975-94); alkaloid from Corydalis cava and other plants; induces catalepsy probably due to its antagonism of DOPAMINE

Also Known As:

Networked: 26 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Catatonia 09/01/1957 - "[Electropometric study in cats with experimental catatonia induced by bulbocapnine]." 02/01/1990 - "I could reproduce the catatonia in animals with several toxics (in the beginning with de Jong from Amsterdam with bulbocapnine and afterwards with other toxins). " 01/01/1958 - "[Bulbocapnine catatonia, its synergists and antagonists]." 03/01/1957 - "[Behavior of experimental catatonia induced by bulbocapnine in rats under the action of various drugs. " 03/01/1957 - "[Behavior of experimental catatonia induced by bulbocapnine in rats under the action of various drugs. "
2.	Catalepsy 11/01/1988 - "The compound did not show cataleptogenic activity and even antagonized the catalepsy evoked by bulbocapnine. " 06/01/1973 - "Brain areas associated with bulbocapnine catalepsy." 08/01/1965 - "The participation of ventral and dorsal hippocampus in the retention of conditioned reaction in the course of bulbocapnine catalepsy." 09/01/1958 - "[Pharmacological analysis of bulbocapnine-induced catalepsy in the mouse]." 12/01/1955 - "[Modifications of cortical excitability and of various subcortical structures during catalepsy induced with bulbocapnine in cats]."
3.	Body Weight (Weight, Body) 11/01/1985 - "It was shown that bulbocapnine (an antagonist of dopamine) administered to the Wistar rats at a dose of 40 mg/kg body weight caused catalepsy, depressed the motor cortex excitability, and raised the threshold of the generalized Jacksonian-type convulsions. " 01/01/1982 - "It was shown that bulbocapnine (an antagonist of dopamine) administered to the Wistar rats in a dose of 40 mg/kg body weight caused catalepsy, depressed the motor cortex excitability and raised the threshold of the generalized Jacksonian-type convulsions. "
4.	Vomiting 03/01/1975 - "In conscious dogs, pimozide abolished apomorphine-induced emesis (an effect mediated by DA receptors in the central nervous system) whereas bulbocapnine had no effect. "
5.	Tremor (Tremors) 07/01/1947 - "Bulbocapnine in postencephalitic parkinsonism; graphic demonstration of the tremor by means of electrocardiographic tracings."

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Pimozide (Orap)
3.	Pentylenetetrazole (Metrazol)
4.	Iproniazid
5.	Colchicine
6.	Apomorphine
7.	Amphetamine (Amfetamine)