3- ((2'- carboxybiphenyl- 4- yl)methyl)- 2- cyclopropyl- 7- methyl- 3H- imidazo(4,5- b)pyridine

a non-peptide angiotensin II-receptor antagonist; structure given in first source

Also Known As:

(1,1'-Biphenyl)-2-carboxylic acid, 4'-((2-cyclopropyl-7-methyl-3H-imidazo(4,5-b)pyridin-3-yl)methyl)-; E 4177; E-4177; E4177

Networked: 8 relevant articles (4 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 3-((2'-carboxybiphenyl-4-yl)methyl)-2-cyclopropyl-7-methyl-3H-imidazo(4,5-b)pyridine: 8
  - Pyridines: 88
    - 3-((2'-carboxybiphenyl-4-yl)methyl)-2-cyclopropyl-7-methyl-3H-imidazo(4,5-b)pyridine: 8

Experts

1.	Itoh, Shinichi: 1 article (01/2005)
2.	Kawahara, Shinji: 1 article (01/2005)
3.	Kubo, Makoto: 1 article (01/2005)
4.	Matsuzaki, Masunori: 1 article (01/2005)
5.	Tanaka, Masakazu: 1 article (01/2005)
6.	Umeji, Kyoko: 1 article (01/2005)
7.	Umemoto, Seiji: 1 article (01/2005)

Related Diseases

1.	Necrosis 08/01/1999 - "Similarly, degeneration and necrosis of glomeruli were also markedly improved by cilazapril and E-4177 (P<0.01). " 08/01/1999 - "Degeneration and necrosis of tubules were significantly improved by cilazapril and E-4177 treatment (P<0.01). " 08/01/1999 - "Moreover, cilazapril, E-4177, and hydralazine significantly decreased the thickening and necrosis of blood vessels compared with vehicle. "
2.	Infarction (Infarctions) 03/01/1996 - "These findings suggest that the AT1 receptor antagonist, E-4177, has a beneficial effect on the hemodynamics in spite of the lack of any improvement in the infarct size. " 03/01/1996 - "Although the infarct size was not affected by E-4177, its administration ameliorated the elevated end-diastolic pressure and reduced the systolic pressure. " 03/01/1996 - "Among the rats with experimental infarction, treatment with E-4177 significantly decreased the left ventricular weight. "
3.	Hypertrophy 11/01/1997 - "Glomerulosclerosis and glomerular hypertrophy in OLETF rats were improved by cilazapril and E4177 to a comparable extent. "
4.	Hypertension (High Blood Pressure) 07/01/1993 - "These data indicate that E4177 is a potent AT1 Ang II-receptor antagonist that may be clinically useful for the treatment of cardiovascular diseases such as hypertension."
5.	Cardiovascular Diseases (Cardiovascular Disease) 07/01/1993 - "These data indicate that E4177 is a potent AT1 Ang II-receptor antagonist that may be clinically useful for the treatment of cardiovascular diseases such as hypertension."

Related Drugs and Biologics

1.	Cilazapril
2.	benzocycloheptapyridine
3.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
4.	Angiotensin Receptor Antagonists
5.	NADPH Oxidases (NAD(P)H oxidase)
6.	Phentolamine (Z-Max)
7.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
8.	Insulin (Novolin)
9.	Hydralazine (Apresoline)
10.	Glucose (Dextrose)