MHC class II transactivator protein

a major histocompatibility complex class II transactivator; essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter; defects in MHC2TA are a cause of BARE LYMPHOCYTE SYNDROME type II (BLS II), a severe form of SCID; RefSeq NM_000246 (human); NM_007575 (mouse)

Also Known As:

Networked: 105 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Accolla, Roberto S: 5 articles (10/2014 - 05/2003)
2.	Gascoyne, Randy D: 4 articles (11/2015 - 11/2009)
3.	Steidl, Christian: 3 articles (11/2015 - 03/2011)
4.	Rimsza, Lisa M: 3 articles (11/2015 - 11/2009)
5.	Mortara, Lorenzo: 3 articles (09/2010 - 06/2006)
6.	De Lerma Barbaro, Andrea: 3 articles (09/2010 - 06/2006)
7.	Olsson, Tomas: 3 articles (07/2009 - 05/2005)
8.	Swanberg, Maria: 3 articles (07/2009 - 05/2005)
9.	Lidman, Olle: 3 articles (07/2009 - 05/2005)
10.	Piehl, Fredrik: 3 articles (07/2009 - 05/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2013 - "To study anti-tumor effects of exosomes from class II transactivator (CIITA) gene transfected CT26 cells. " 09/01/2005 - "To study the effect of MHC class II transactivator(CIITA ) on the expression of MHC class I/II molecules, CD80 and CD86 molecules on dendritic cells(DCs), and explor the use of DCs modified by CIITA gene in the biotherapy of tumors. " 11/17/2015 - "We analyzed 45 primary PMBCL tumor biopsies and 3 PMBCL-derived cell lines for the presence of genetic alterations involving the major histocompatibility complex (MHC) class II transactivator CIITA and found frequent aberrations consisting of structural genomic rearrangements, missense, nonsense, and frame-shift mutations (53% of primary tumor biopsies and all cell lines). " 07/01/2015 - "Class II transactivator (CIITA) mediates transcriptional repression of pdk4 gene by interacting with hypermethylated in cancer 1 (HIC1)." 03/10/2015 - "These mutations were associated with a signature of decreased antigen presentation characterized by reduced transcript and protein abundance of MHC class II on tumor B cells, in line with the role of CREBBP in promoting class II transactivator (CIITA)-dependent transcriptional activation of these genes. "
2.	Melanoma (Melanoma, Malignant) 05/31/2011 - "In this study, we have established an MHC class II molecule-expressing B16F1 murine melanoma cell line (B16F1- CIITA) by transduction of the CIITA (Class II transactivator) gene. " 02/01/2007 - "In this study, we measured levels of constitutive and IFN-gamma-induced expression of MHC class II molecules, analysed the expression of CIITA and investigated the association between MHC class II transactivator polymorphism and expression of different MHC class II molecules in a large panel of melanoma cell lines obtained from the European Searchable Tumour Cell Line Database. " 01/01/2015 - "Class II transactivator expression in melanoma cells facilitates T-cell engulfment." 01/01/2011 - "We also show that bryostatin-1 treatment of melanoma cells increases class II protein levels by upregulating the class II transactivator (CIITA) gene. " 12/01/2004 - "Class II transactivator (CIITA) isoform expression and activity in melanoma."
3.	Lymphoma (Lymphomas) 09/15/2002 - "This study demonstrates that the variation in MHC class II Ag expression among clones of L1210 lymphoma is due to differences in the expression of the class II transactivator (CIITA). " 04/01/2004 - "Defective class II transactivator expression in a B lymphoma cell line." 09/15/2002 - "DNA alkylating agents alleviate silencing of class II transactivator gene expression in L1210 lymphoma cells."
4.	Astrocytoma (Pilocytic Astrocytoma) 08/01/2002 - "To develop a model of CD4-infected APC interaction, we have transfected the U373MG astrocytoma cell line with the class II transactivator (CIITA). " 05/15/1998 - "Kinase inhibitors abrogate IFN-gamma-induced class II transactivator and class II MHC gene expression in astroglioma cell lines." 05/15/1998 - "In this study, we examined the necessity of ser/thr and tyr kinase activity for IFN-gamma-induced stimulation of class II MHC gene expression in the human astroglioma cell lines CRT and CH235, as well as the involvement of these kinases in IFN-gamma-induced expression of the class II transactivator (CIITA), a protein critical for IFN-gamma-induced transcription of class II MHC genes. "
5.	Shock 05/01/2000 - "In this study it is shown that heparin can prevent normal induction of the class II transactivator and heat shock cognate protein-70 in an IFN-gamma-treated endothelial cell line. "

Related Drugs and Biologics

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2.	Staphylococcal Protein A (A, Protein)
3.	Heparin (Liquaemin)
4.	Interferon-gamma (Interferon, gamma)
5.	HLA-DR Antigens (HLA-DR)
6.	Transcription Factors (Transcription Factor)
7.	Messenger RNA (mRNA)
8.	regulatory factor X transcription factors
9.	Non-Receptor Type 22 Protein Tyrosine Phosphatase
10.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)

Related Therapies and Procedures

1.	Immunotherapy