2'-deoxy-2'-fluoroguanosine

has activity in human respiratory epithelial cells against both influenza A & B viruses

Also Known As:

2'-DFGS; Guanosine, 2'-deoxy-2'-fluoro-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Guanosine: 1156
        Deoxyguanosine: 166
        2'-deoxy-2'-fluoroguanosine: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Guanosine: 1156
      - Deoxyguanosine: 166
        2'-deoxy-2'-fluoroguanosine: 4
  - Deoxyribonucleosides: 34
    - Deoxyguanosine: 166
      - 2'-deoxy-2'-fluoroguanosine: 4

Experts

1.	Boreko, I: 1 article (09/2001)
2.	Mikhaĭlopulo, I A: 1 article (09/2001)
3.	Pavlova, N I: 1 article (09/2001)
4.	Zaĭtseva, G V: 1 article (09/2001)

Related Diseases

1.	Human Influenza (Influenza) 08/01/1993 - "The exceptional activity of 2'-deoxy-2'-fluoroguanosine in human respiratory epithelial cells against both influenza A and B viruses makes this compound an interesting candidate for further investigation." 09/01/2001 - "[Antiviral activity of 2'-deoxy-2'-fluoroguanosine against influenza and herpes simplex viruses in cultured cells]."
2.	Infections 11/01/1995 - "The nucleoside analog 2'-deoxy-2'-fluoroguanosine (2'-fluorodGuo) is phosphorylated by cellular enzymes and reversibly inhibits influenza virus replication in chick embryo cells within the first 4 h of infection. " 08/01/1994 - "Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation. "
3.	Inflammation (Inflammations) 08/01/1994 - "Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation. "
4.	Fever (Fevers) 08/01/1994 - "Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation. "
5.	Body Weight (Weight, Body) 08/01/1994 - "Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation. "

Related Drugs and Biologics

1.	Prodrugs
2.	Nucleosides
3.	Enzymes
4.	Antiviral Agents (Antivirals)