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2'-deoxy-2'-fluoroguanosine
has activity in human respiratory epithelial cells against both influenza A & B viruses
Also Known As:
2'-DFGS; Guanosine, 2'-deoxy-2'-fluoro-
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleosides: 360
Guanosine: 1156
Deoxyguanosine: 166
2'-deoxy-2'-fluoroguanosine: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Purine Nucleosides: 360
Guanosine: 1156
Deoxyguanosine: 166
2'-deoxy-2'-fluoroguanosine: 4
Deoxyribonucleosides: 34
Deoxyguanosine: 166
2'-deoxy-2'-fluoroguanosine: 4
Experts
1.
Boreko, I
: 1 article (09/2001)
2.
Mikhaĭlopulo, I A
: 1 article (09/2001)
3.
Pavlova, N I
: 1 article (09/2001)
4.
Zaĭtseva, G V
: 1 article (09/2001)
Related Diseases
1.
Human Influenza (Influenza)
08/01/1993 - "
The exceptional activity of 2'-deoxy-2'-fluoroguanosine in human respiratory epithelial cells against both influenza A and B viruses makes this compound an interesting candidate for further investigation.
"
09/01/2001 - "
[Antiviral activity of 2'-deoxy-2'-fluoroguanosine against influenza and herpes simplex viruses in cultured cells].
"
2.
Infections
11/01/1995 - "
The nucleoside analog 2'-deoxy-2'-fluoroguanosine (2'-fluorodGuo) is phosphorylated by cellular enzymes and reversibly inhibits influenza virus replication in chick embryo cells within the first 4 h of infection.
"
08/01/1994 - "
Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation.
"
3.
Inflammation (Inflammations)
08/01/1994 - "
Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation.
"
4.
Fever (Fevers)
08/01/1994 - "
Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation.
"
5.
Body Weight (Weight, Body)
08/01/1994 - "
Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation.
"
Related Drugs and Biologics
1.
Prodrugs
2.
Nucleosides
3.
Enzymes
4.
Antiviral Agents (Antivirals)