angelmicin B
from Microbispora sp.AA9966; MF C85-H112-O37; protein tyrosine kinase inhibitor
Also Known As:
Angelmicin B
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Bio-Agent Context: Research Results
Related Diseases
| 1. | Myeloid Leukemia (Leukemia, Myelocytic)
06/01/1996
- " A similar concentration of angelmicin B inhibited the growth of the myeloid leukemia cell lines K562, HEL, KU812, ML-1, U937 and THP-1, but did not induce differentiation of these cells significantly. " 06/01/1996
- " We investigated the effect of angelmicin B on the proliferation and differentiation of the HL-60 human myeloid leukemia cell line. " 06/01/1996
- " Angelmicin B, a new inhibitor of oncogenic signal transduction, inhibits growth and induces myelomonocytic differentiation of human myeloid leukemia HL-60 cells." 06/01/1996
- " Angelmicin B caused the dose-dependent inhibition of cell proliferation and induction of differentiation along the myelomonocytic pathway, as determined by morphological changes, nitroblue tetrazolium (NBT) reduction, and non-specific esterase and lysozyme activities at concentrations ranging from 0.1 to 0.5 microgram/ml. Also, it induced significantly the differentiation of mouse myeloid leukemia M1 cells. "
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